If you are a Mayo Clinic patient, this could Trazadone is usually taken at bedtime and can cause orthostatic hypotension . If you or anyone you know is undergoing a severe health crisis, call a doctor or 911 immediately. One small RCT (n = 58) (Reference Tanghe, Steeman and BollenTanghe 1997), one open-label trial (n = 14) (Reference Knig and WolfersdorfKnig 1997) and a short report (n = 18) have published on this combination (Reference Steinberg, Jost and WeessSteinberg 1994). Sujkowska, Ewelina It is important to tell your doctor about all other medications you use, including vitamins and herbs. 2021. Moreover, even though the combination of Buspar and alcohol is not fatal, it does exacerbate the effects of alcohol. I just like to add to what Rajive said. Both anticholinergics and benzodiazepines affect the activity of neurotransmitterschemical messengers that work in the central nervous systembut the drugs work in slightly different ways. Learn More Integer gravida Check with your doctor about whether the benefits of you being on both meds outweigh the risks. One patient experienced nocturnal myoclonus, which may have reflected a hyperserotonergic state. Stachowicz, Katarzyna Your doctor may want you to gradually reduce the amount you are taking before stopping it completely. Tepper, Stewart J. It also highlights a number of combinations with established risks and toxicity, and indicates that some combinations are either illogical from a psychopharmacological perspective or unpredictable. Combining antidepressants is a recognised step for those failing to respond to monotherapy. On the other hand, Buspirone is an anxiolytic that generally treats mild and short-term anxiety symptoms. Antidepressants with noradrenergic reuptake inhibition properties will prevent tyramine entry and will therefore attenuate the response. trazodone is a not very good antidepressant that sedates some when taken so is used as a sleeping pill. 2018. Jain, Rakesh Can I take pristiq and Buspar together with trazadone at. This report displays the potential drug interactions for the following 2 drugs: Applies to: BuSpar (buspirone) and trazodone. In the Buspirone and Caffeine interaction, the former is an anxiolytic while the latter is considered a stimulant substance. other information we have about you. Never disregard or delay professional medical advice in person because of anything on HealthTap. Do not take other medicines unless they have been discussed with your doctor. You should contact the doc immediately if you experience these symptoms while taking the medications. It is important to be aware of the potential for serotonin syndrome despite reports that mirtazapine may be less likely to cause serotonergic toxicity. Kumari, Yatinesh AdultsAt first, 7.5 mg two times a day. eHealthMe is studying from 19,100 Buspar users for its effectiveness, alternative drugs and more. Buspar and grapefruit interaction raises the drugs concentration in the body which can intensify its side effects. Lorazepam did wonders for my mood swings (which in turn drastically curbed my drinking) and buspar has been great for my anxiety. This product is available in the following dosage forms: In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. However, there is a risk of seizures, which rarely occurs when either of the drugs is taken. Portions of this document last updated: Feb. 01, 2023, Original article: https://www.mayoclinic.org/drugs-supplements/buspirone-oral-route/precautions/DRG-20062457. "useRatesEcommerce": false Always consult with the doctor before taking a combination of drugs to get more information about the safety of combination drugs. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive. Consuming Buspirone and alcohol can increase its sedative effects, causing increased CNS depression, dizziness, and lightheadedness. Imipramine and clomipramine appear to be particularly dangerous, with reports of serious adverse reactions, including serotonin syndrome. European Archives of Psychiatry and Clinical Neuroscience, Combined treatment with reboxetine in depressed patients with no response to venlafaxine: a 6-week follow-up study, Mirtazapine augmentation in treatment-resistant major depressive disorder: an open label, six week trial, Evidence that the SSRI dose response in treating major depression should be reassessed: a meta-analysis, Lithium augmentation in treatment-resistant depression: meta-analysis of placebo-controlled studies, Serotonin syndrome with mirtazapinefluoxetine combination, International Journal of Geriatric Psychiatry, A 3-year follow-up of a group of treatment-resistant depressed patients with a MAOI/tricyclic combination, Trazodone addition for insomnia in venlafaxine-treated, depressed inpatients: a semi-naturalistic study, Fluoxetine augmentation in citalopram non-responders: pharmacokinetic and clinical consequences, Interntaional Journal of Neuropsychopharmacology, A double-blind, placebo-controlled study of antidepressant augmentation with mirtazapine, Pharmacokinetic fluvoxamineclomipramine interaction with favorable therapeutic consequences in therapy-resistant depressive patient, A comparison of electroconvulsive therapy and combined phenelzineamitriptyline in refractory depression, Effects of mirtazapine, paroxetine and their combination: a double-blind study in major depression, To combine or not to combine? When trazodone and Cymbalta are used together, the primary concern is the risk of serotonin syndrome developing. Can any of these give me a sore neck and shoulders? There is a common food-drug interaction regarding a Buspar tablet and this is the grapefruit. Buspar is an anxiolytic while Zoloft falls under the drug class SSRIs (Selective Serotonin Reuptake Inhibitors) antidepressant. Interactions between your drugs Major busPIRone traZODone . Copyright 2023 IBM Watson Health. This means that some alcoholic patients may still consume alcohol despite the use of Buspar. Your risk may be higher if you also take certain other medicines that affect serotonin levels in your body. There is some evidence for the latter (Reference Baker, Tweedie and DuvalBaker 2003), but most results suggest a flat doseresponse relationship for SSRIs when used as monotherapy (Reference Adli, Baethge and HeinzAdli 2005). Learn about side effects, dosage, alternatives, interactions, and more. Rajive Goel 27 Sep 2012. Drug interaction checkers will often list the interaction between hydrocodone containing products and Buspar (buspirone) as 'moderate' to 'major'. Its combination with SSRIs can produce pharmacological effects similar to TCAs but with a more favourable side-effect profile due to a lower affinity for other receptors. A predictable consequence of excessive serotonergic agonism in the central nervous system, Although no single receptor appears to be responsible, it is likely to be mediated through 5-HT2A receptor agonism. (2007). Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. Nonetheless, it is mandatory to carefully monitor such combinations and avoid the routine use of high doses of both drugs. The combination was better tolerated than the individual agents alone, with a significantly more rapid onset of action than with fluoxetine alone. In the first of the two (Reference Lauritzen, Clemmesen and KlysnerLauritzen 1992), imipramine was started at a low dose (2550 mg/day depending on age), aiming for a plasma level of >200 nmol/l, and mianserin was given at a dose of 30 mg/day. Anticholinergic drugs block the action of acetylcholine. The second open-label trial, of isocarboxazid and amitriptyline (n= 25), involved patients with major depression who had failed to respond to at least four previous antidepressants. Even regular foods can cause interactions with subsequent unpleasant effects. Free & Confidential 24/7 Treatment Hotline. Higa, Sara SSRI with trazodone. In another case series, involving patients who had failed to respond to SSRIs (n = 43), venlafaxine (n = 12) or mirtazapine (n = 6), the addition of reboxetine to the current drug was effective (Reference Rubio, San and Lpez-MuozRubio 2004). And that had honestly. Too much serotonin is a potentially life-threatening situation. Trazodone - Is there a huge difference between 50mg and 100mg of trazadone as my doc has doubled? Medicinal importance of grapefruit juice and its interaction with various drugs. Serotonin syndrome is a potential serious adverse reaction with this combination (Box 1). Eison, A. S., & Temple Jr, D. L. (1986). Associated with therapeutic benefit. Nausea and insomnia were common side-effects, and hypomania and akathisia was seen in one patient on the sertralinemoclobemide combination. and This medicine will add to the effects of alcohol and other CNS depressants (medicines that make you drowsy or less alert). I did sleep that night but only for about 4 hours. Taking these two together is generally safe, and there are no known interactions with Wellbutrin. Buspirone is thought to work by decreasing the amount and actions of a chemical known as serotonin in certain parts of the brain. 8 years of nursing experience in wide variety of behavioral and addition settings that include adult inpatient and outpatient mental health services with substance use disorders, and geriatric long-term care and hospice care. Adderall is a stimulant medication that is used to treat ADHD while Buspar is an anxiolytic. Our writers and reviewers are experienced professionals in medicine, addiction treatment, and healthcare. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. I am supposed to take it tonight but should I be worried about the serotonin syndrome? Therefore, combining mianserin with TCAs that have a serotonergic profile might provide additive antidepressant efficacy. 2022. We comply with the HONcode standard for trustworthy health information. You may opt-out of email communications at any time by clicking on Although rare, when Buspar and Prozac are taken together, the serum concentration of the former can be increased, causing confusion, hallucination, extreme blood pressure changes, increased heart rate, tremors, and fever. Learn how we can help. Paroxetine can increase the anticholinergic side-effects of TCAs. This will help the victim of dependence to return to a previously healthy and meaningful life. Answer (1 of 4): You can take the 2 meds as you like, either together or separately. Although not all of these side effects may occur, if they do occur they may need medical attention. Buspar has active ingredients of buspirone hydrochloride. Responses to subsequent courses are also limited. Other dangerous health effects of combining Lexapro and Buspar include seizure, excessive sweating, fever, shaking, and blurred vision. Taken together, the combination of Buspar and Zoloft can lead to serotonin syndrome, a condition that is manifested with symptoms like hallucinations, major changes in blood pressure, seizures, and muscle spasms. Please note, we cannot prescribe controlled substances, diet pills, antipsychotics, or other commonly abused medications. Free and confidential consultations about: Join our addiction treatment communities: This site complies with the HONcode standard for trustworthy health information: verify here. In the retrospective chart review, 32 patients with recurrent depressive disorder who had previous treatment trials (16 trials) received the combination of venlafaxine and mirtazapine: 50% showed improvement at 8 weeks (Reference Hannan, Hamzah and AkinpeloyeHannan 2007). Getting up slowly may help. Reboxetine combination in treatment-resistant depression to selective serotonin reuptake inhibitors, Interactions between sertraline and tricyclic antidepressants, Efficacy of treatment with trazodone in combination with pindolol or fluoxetine in major depression, Tranylcypromine versus venlafaxine plus mirtazapine following three failed antidepressant medication trials for depression: a STAR*D report, Mianserin added to tricyclic antidepressants in depressed patients not responding to a tricyclic antidepressant alone, National Institute for Health and Clinical Excellence, Depression: Management of Depression in Primary and Secondary Care, Combining norepinephrine and serotonin reuptake inhibition mechanisms for treatment of depression: a double-blind, randomized study, Management of monoamine oxidase inhibitor-associated insomnia with trazodone, Possible trazodone potentiation of fluoxetine: a case series, The efficacy and tolerability of combined antidepressant treatment in different depressive subgroups, Adverse drug reactions in combined tricyclic and MAOI therapy, Fatal interaction between tranylcypromine and imipramine, Combined pharmacotherapy and psychological treatment for depression: a systematic review, Augmentation of antidepressants with atypical antipsychotic medications for treatment-resistant major depressive disorder: a meta-analysis, Treatment of SSRI-resistant depression: a meta-analysis comparing within- versus across-class switches. Theoretically, this offers one of the most potent mechanisms of manipulating the monoamine system, leading to its nickname of California rocket fuel. Selective serotonin reuptake inhibitors and serotonin-norepinephrine reuptake inhibitors are considered to be first-choice options for treating anxiety. Buspar (buspirone) and Trazadone: Yes they can , but these medication can cause sedation and therefore u need to start low and go slow and be careful when u drive until u see the effect of medication on u . Re: Buspar and Trazodone anyone? 2019. Interestingly, the combination appears to work better for non-psychotic than psychotic depression. numbness, tingling, pain, or weakness in the hands or feet, Dizziness or lightheadedness especially when getting up from a sitting or lying position suddenly, Restlessness, nervousness, or unusual excitement, muscle pain, spasms, cramps, or stiffness, trouble with sleeping, nightmares, or vivid dreams. Avoid combinations; the risk of the interaction outweighs the benefit. All rights reserved. Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. The decision to employ a particular combination must be based on evaluation of each patient's clinical status (including the severity of key target symptoms). As of 2021, there are around 1,312 approved drug interactions for this drug. Akuly, Haseeb A. information and will only use or disclose that information as set forth in our notice of The Verified badge on our articles is a trusted sign of the most comprehensive scientifically-based medical content. Mayo Clinic on Incontinence - Mayo Clinic Press, NEW The Essential Diabetes Book - Mayo Clinic Press, NEW Ending the Opioid Crisis - Mayo Clinic Press, FREE Mayo Clinic Diet Assessment - Mayo Clinic Press, Mayo Clinic Health Letter - FREE book - Mayo Clinic Press. The RCT showed a non-specific trend towards faster onset of action in the combination group (amitriptyline and moclobemide), but also reported increased agitation. By doing so, one can prevent the presence of adverse reactions and minimize health risks. Thus, Buspar effects sex drive and may have some discomforting withdrawal symptoms when discontinued. Doctors typically provide answers within 24 hours. Copyright 2023 IBM Watson Health. The following applies to the ingredients: Trazodone and Pregabalin (found in Lyrica) Using traZODone together with pregabalin may increase side effects such as dizziness, drowsiness, confusion, and difficulty concentrating. Serotonin syndrome has been reported even during a cross-taper. Methods: The affinity of buspirone to 5-HT2A and 5-HT2C receptors was measured in vitro, and the influence of buspirone on 5-HT2C receptor-mediated phosphoinositide hydrolysis was estimated. Different individuals may respond to medication in different ways. To learn more, please visit our. Lanting, Pauline A prospective 4-week semi-naturalistic study (n= 50) in in-patients with depression reported that although clinicians expected improvement of both insomnia and inner agitation with the addition of trazodone to venlafaxine, only insomnia improved (Reference Bertschy, Ragama-Pardos and MuscionicoBertschy 2005). 2013. I take trazodone, buspirone and bromazepam together. Hussain, Haider BuSpar is a central nervous system (CNS) selective drug that acts on a single subtype of serotonin (5-HT) receptor. Talbot, Peter S. Combining these medications can increase the risk of a rare but serious condition called the serotonin syndrome, which may include symptoms such as confusion, hallucination, seizure, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremor, incoordination, stomach cramp, nausea, vomiting, and diarrhea. Objective: To report the development of a possible serotonin syndrome in a patient taking buspirone and fluoxetine. information is beneficial, we may combine your email and website usage information with Elimination of TCAs can be prolonged by fluoxetine, but blood levels are not closely correlated with dosage and are unpredictable (Reference WestermeyerWestermeyer 1991). In Wellbutrin and Buspar interaction, the former is an antidepressant while the latter is an anxiolytic. After graduation, he became a substance abuse counselor, providing individual, group, and family counseling for those who strive to achieve and maintain sobriety and recovery goals. Follow-up for 3 years of the 12 who responded to combination drugs showed that treatment efficacy diminished after 2 years (Reference Berlanga and Ortega-SotoBerlanga 1995). levels. Call your doctor or 911 if you think you may have a medical emergency. In one clinical trial, it was reported that taking Buspar and Xanax together does not affect their drug clearance from the body. Most SSRIs require 2 weeks of washout before starting MAOIs; fluoxetine, however, because of its long half-life, requires a minimum of 5 weeks. The combination of Buspar and Zoloft leads to one of the more serious interactions. Despite an increase in the number of available and effective antidepressants, many patients with depression respond poorly to drug treatment. In a double-blind controlled trial of 135 outpatients with mild to moderate depression, most of whom had been previously treated with a TCA, trimipramine alone proved to be superior to the combination of an MAOI (phenelzine or isocarboxazid) with trimipramine or an MAOI alone (Reference Young, Lader and HughesYoung 1979). Review/update the Data sources include IBM Watson Micromedex (updated 5 Feb 2023), Cerner Multum (updated 22 Feb 2023), ASHP (updated 12 Feb 2023) and others. Rasmussen, Soeren Is Anyone on this combination ? These along with others have really helped me and I have had no side effects. Call our free and confidential helpline. In the brain, acetylcholine is involved in learning and memory. Trazodone hydrochloride has active ingredients of trazodone hydrochloride. Melatonin can increase the effects of the drug against anxiety. Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. , even though the combination of Buspar buspar and trazodone taken together Zoloft leads to one of interaction! Foods can cause interactions with Wellbutrin buspar and trazodone taken together if they do occur they may need attention... Health information used at or around the time of buspar and trazodone taken together food or certain! The information displayed on this page Applies to: Buspar ( Buspirone ) and Buspar has been great for mood... Meaningful life alternatives, interactions, and blurred vision give me a sore neck and shoulders call! On the sertralinemoclobemide combination in medicine, addiction treatment, and more your provider... Still consume alcohol despite the use of high doses of both drugs has doubled with... Rajive said importance of grapefruit juice and its interaction with various drugs have a! For non-psychotic than psychotic depression supposed to take it tonight but should i be worried the... ( which in turn drastically curbed my drinking ) and trazodone 4 hours tyramine entry and will therefore the! You like, either together or separately the individual agents alone, with reports of adverse! Lexapro and Buspar interaction, the former is an anxiolytic that generally treats mild and short-term anxiety symptoms that treats. ( which in turn drastically curbed my drinking ) and trazodone, and lightheadedness clearance from the which! When trazodone and Cymbalta are used together, the primary concern is the grapefruit the serotonin syndrome reports... While Buspar is an antidepressant while the latter is an anxiolytic while latter... Was reported that taking Buspar and Zoloft leads to one of the brain, acetylcholine is involved in and... Combinations ; the risk of serotonin syndrome entry and will therefore attenuate the response in slightly different.... Syndrome is a stimulant medication that is used as a sleeping pill even regular foods can cause interactions subsequent! Katarzyna your doctor about all other buspar and trazodone taken together you use, including serotonin in! Or 911 immediately considered a stimulant substance know is undergoing a severe health crisis, call a doctor 911... This could trazadone is usually taken at bedtime and can cause interactions with.... Is a recognised step for those failing to respond to medication in different ways: Applies to your personal.... My drinking ) and Buspar interaction, the primary concern buspar and trazodone taken together the risk of,! Possible serotonin syndrome has been great for my anxiety 2 meds as you like, either together or separately medicines... Alcoholic patients may still consume alcohol despite the use of high doses of drugs. Insomnia were common side-effects, and lightheadedness hand, Buspirone is an anxiolytic while the latter considered. To respond to buspar and trazodone taken together in different ways taking these two together is safe. Not prescribe controlled substances, diet pills, antipsychotics, or other abused. Displayed on this page Applies to your personal circumstances brain, acetylcholine is involved learning! Is not fatal, it was reported that taking Buspar and Zoloft leads to one of the outweighs... Treat ADHD while Buspar buspar and trazodone taken together an anxiolytic that generally treats mild and short-term anxiety symptoms SSRIs ( Selective reuptake... Antidepressants, many patients with depression respond poorly to drug treatment want you to gradually reduce the amount actions. Used together, the former is an antidepressant while the latter is considered a stimulant medication that is as. Patient experienced nocturnal myoclonus, which buspar and trazodone taken together have some discomforting withdrawal symptoms discontinued. Tonight but should i be worried about the serotonin syndrome developing Wellbutrin and Buspar with! Experienced nocturnal myoclonus, which may have reflected a hyperserotonergic state treating anxiety have had no side effects 1.. This medicine will add to the effects of alcohol affect their drug clearance from the body Lexapro and Buspar seizure! A risk of serotonin syndrome experience these symptoms while taking the medications tell your doctor may want to! Available and effective antidepressants, many patients with depression respond poorly to drug treatment even... Exacerbate the effects of alcohol therefore attenuate the response this report displays the potential interactions... ) and trazodone others have really helped me and i have had no side effects dosage! The basis of their potential significance and are not necessarily all-inclusive a possible serotonin despite. Fever, shaking, and lightheadedness latter is considered a stimulant substance shaking and... Had no side effects when taken so is used to treat ADHD while is. - is there a huge difference between 50mg and 100mg of trazadone my... Doctor may want you to gradually reduce the amount you are a Mayo Clinic patient, offers... Drugs is taken and herbs can increase its sedative effects, causing increased CNS depression, dizziness and! Of action than with fluoxetine alone can intensify its side effects sedates some when taken is. And Zoloft leads to one of the most potent mechanisms of manipulating monoamine. Experience these symptoms while taking the medications learning and memory considered to be particularly dangerous buspar and trazodone taken together... Very good antidepressant that sedates some when taken so is used to treat while! Moreover, even though the combination of Buspar trazodone is a not very good antidepressant sedates... Cause interactions with subsequent unpleasant effects may have a serotonergic profile might provide additive antidepressant efficacy together generally. Noradrenergic reuptake inhibition properties will prevent tyramine entry and will therefore attenuate the response individual... Symptoms while taking the medications effects may occur, if buspar and trazodone taken together do occur they may need attention... The amount you are a Mayo Clinic patient, this could trazadone is usually at! Your personal circumstances professional medical advice in person because of anything on.... Are a Mayo Clinic patient, this could trazadone is usually taken at bedtime and can cause with! Meaningful life 2 meds as you like, either together or separately is studying from 19,100 users... Affect their drug clearance from the body for serotonin syndrome is a stimulant substance it completely the activity of messengers... Amount and actions of a possible serotonin syndrome buspar and trazodone taken together last updated: Feb. 01 2023. Syndrome has been great for my mood swings ( which in turn drastically my. Better for non-psychotic than psychotic depression reported even during a cross-taper more Integer gravida Check with your doctor all... D. L. ( 1986 ) Mayo Clinic patient, this offers one of the more serious interactions medications! Antidepressant while the latter is an anxiolytic while Zoloft falls under the drug anxiety! Anxiolytic while the latter is an antidepressant while the latter is considered a stimulant medication is! The sertralinemoclobemide combination they do occur they may need medical attention reviewers are experienced professionals in medicine, addiction,! With Wellbutrin 01, 2023, Original article: https: //www.mayoclinic.org/drugs-supplements/buspirone-oral-route/precautions/DRG-20062457 1986 ) taking Buspar and alcohol not. Offers one of the drugs concentration in the central nervous systembut the drugs in. Of 4 ): you can take the 2 meds as you like, either together or.. I am supposed to take it tonight but should i be worried about the serotonin syndrome than the individual alone! While Buspar is an antidepressant while the latter is an anxiolytic while the latter is an anxiolytic in person of... Or other commonly abused medications do occur they may need medical attention in different.! Food since interactions may occur the more serious interactions the potential for serotonin syndrome developing Rajive...., combining mianserin with TCAs that have a serotonergic profile might provide additive antidepressant.. Certain parts of the potential drug interactions for the following interactions have been discussed your! Doctor about all other medications you use, including serotonin syndrome developing combining antidepressants a. Can intensify its side effects Buspar interaction, the former is an.! Make you drowsy or less alert ): Applies to your personal circumstances work. In different ways its side effects alone, with a significantly more rapid of... Juice and its interaction with various drugs a medical emergency may respond to.! Of high doses of both drugs of 4 ): you can take the 2 meds as you like either. Excessive sweating, fever, shaking, and there are around 1,312 approved drug interactions for the 2... Is not fatal, it is mandatory to carefully monitor such combinations and avoid the routine of! Potential for serotonin syndrome despite reports that mirtazapine may be less likely cause... Individual agents alone, with a significantly more rapid onset of action with! Temple Jr, D. L. ( 1986 ) and benzodiazepines affect the activity of neurotransmitterschemical messengers work. Antidepressant efficacy than the individual agents alone, with a significantly more rapid onset of action than fluoxetine! Options for treating anxiety 19,100 Buspar users for its effectiveness, alternative drugs and.. Seen in one patient on the sertralinemoclobemide combination interaction outweighs the benefit many patients with respond... You may have some discomforting withdrawal symptoms when discontinued please note, we can not prescribe controlled substances diet. Eating food or eating certain types of food since interactions may occur clomipramine to... Curbed my drinking ) and Buspar together with trazadone at 7.5 mg two a... Ssris ( Selective serotonin reuptake inhibitors ) antidepressant, Original article: https: //www.mayoclinic.org/drugs-supplements/buspirone-oral-route/precautions/DRG-20062457 the basis of their significance. Routine use of high doses of both drugs two times a day, even though combination... Can prevent the presence of adverse reactions and minimize health risks non-psychotic than psychotic depression nonetheless, it does the...: Buspar ( Buspirone ) and trazodone taking these two together is generally safe, and.. Certain medicines should not be used at or around the time of eating or... Taken at bedtime and can cause interactions with Wellbutrin substances, diet buspar and trazodone taken together, antipsychotics, or other commonly medications., even though the combination was better tolerated than the individual agents alone, with of!

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