(reader 1: board-certified radiologist with over nine years of experience, reader 2: radiology resident with more than four years of experience). PET Clin. Follows et al, British Journal of Haematology, 2014, 166, 3449. ; Bogue, M.K. permission provided that the original article is clearly cited. However, NCCN imaging guidelines for lymphoma surveillance state that it is acceptable to perform chest radiography or CT of the chest every six to 12 months for the first two years and then yearly for the next three to five years posttreatment.41 Surveillance imaging with PET-CT scans following complete remission is not recommended.40,41 Disease marker research is ongoing, examining minimal residual disease measurements, a polymerase chain reactionbased method that looks at identifying tumor-specific DNA sequences.41, All patients with lymphoma should receive pneumococcal vaccination initially with a 13-valent pneumococcal conjugate vaccine (Prevnar 13), followed at least eight weeks later by a 23-valent pneumococcal polysaccharide vaccine (PPSV23; Pneumovax 23) and then another PPSV23 at least five years later.44 Patients receiving antiB-cell antibodies should not receive annual influenza vaccination, and administration of live vaccines is contraindicated during chemotherapy. Radiomic features were extracted using PyRadiomics (Version 3.0)25,26, following the instructions of the Image Biomarker Standardisation Initiative (IBSI)27. receives grants for the Department of Radiology fromActelion Pharmaceuticals, Bayer Schering, Bayer Vital, Bristol-Myers Squibb, Charit Research Organisation GmbH, Abbot, BRACCO Group, Deutsche Krebshilfe, Essex Pharma, Guerbet, INC Research, InSightec Ud, IPSEN Pharma, Kendlel MorphoSys AG, Lilly GmbH, MeVis Medical Solutions AG, Nexus Oncology, Novartis, Parexel Clinical Research Organisation Service, Pfizer GmbH, Philipps, Sanofis-Aventis, Siemens, Teruma Medical Corporation, Toshiba, Zukunfsfond Berlin, Amgen, AO Foundation, BARD, BBraun, Boehring Ingelheimer, Brainsgate, CELLACT Pharma, CeloNova Bio-Sciences, North Carolina GlaxoSmithKline Foundation, Jansen, Roehe, Sehumaeher GmbH, Medtronic, Pluristem, Quintiles, Astellas, Chiltern, Respicardia, TEVA, Abbvie, AstraZeneca, Galmed Research and Development. J. Nucl. Article 2023, 13, 445. 2016 Sep;95(9):1521-35. doi: 10.1007/s00277-016-2736-5. ; Bartelink, H.; van Leeuwen, F.E. WebRisk stratification on the basis of Deauville score on PET-CT and the presence of Epstein-Barr virus DNA after completion of primary treatment for extranodal natural killer/T-cell lymphomanasal typea multicentreretrospective analysis [J]. Epub 2017 Dec 10. Non-Hodgkin lymphoma can originate anywhere in the body, with specific subtypes originating in the gastrointestinal tract, skin, or central nervous system. ; Elsafy, U.R. Hodgkin lymphoma typically appears in the supradiaphragmatic lymph nodes. Correlation between SUVmax and CT radiomic analysis using lymph node density in PET/CT-based lymph node staging. Methods 188, 2029. Your email address will not be published. official website and that any information you provide is encrypted 398 (John Wiley & Sons, 2013). An official website of the United States government. Epub 2022 Jul 25. Marani C, Raiola AM, Morbelli S, Dominietto A, Ferrarazzo G, Avenoso D, Giannoni L, Varaldo R, Gualandi F, Grazia D, Lamparelli T, Bregante S, Van Lint MT, Ibatici A, Bovis F, Lemoli RM, Gobbi M, Bacigalupo A, Angelucci E. Biol Blood Marrow Transplant. Rep. 12, 10192. https://doi.org/10.1038/s41598-022-13967-8 (2022). By submitting a comment you agree to abide by our Terms and Community Guidelines. Pretransplant DS/rMTV41% combination and disease status predict the risk of post-transplant treatment failure and will guide risk-stratified approaches in relapsed/refractory cHL. Berenguer, R. et al. Children and adolescents with newly diagnosed stage IA, IB, and IIA classical Hodgkin lymphoma younger than 18 years of age were assigned to treatment group 1 to be treated with two PubMedGoogle Scholar. Expert opinion and clinical review articles, Expert opinion and clinical review article, Non-Hodgkin T-cell and natural killer cell lymphomas, Non-Hodgkin (mucosa-associated lymphoid tissue), Single nodal group or single extralymphatic lesion, Multiple nodal groups on same side of diaphragm or with limited contiguous extralymphatic involvement, Multiple nodal groups on both sides of the diaphragm; may involve the spleen, Serum albumin concentration < 4.0 g per dL (40 g per L), Hemoglobin concentration < 10.5 g per dL (105 g per L), Progressive multifocal leukoencephalopathy, FDG uptake at lymphoma site is mediastinum FDG uptake, FDG uptake at lymphoma site is > mediastinum FDG uptake but < liver FDG uptake, FDG uptake at lymphoma site is > liver FDG uptake at any site, FDG uptake at lymphoma site is substantially > liver FDG uptake or new FDG uptake sites found, Breast: annual screening mammography starting at age 40; history of chest or axilla radiation: start eight to 10 years after treatment or at age 40, whichever comes first; consider annual breast magnetic resonance imaging if chest radiation was received between ages 10 and 30; consider referral to breast subspecialist to discuss possible chemoprevention, Complete blood count, fasting blood glucose, and comprehensive metabolic panel annually, Annual blood pressure screening, lifestyle modification, and treatment of obesity, hypertension, and tobacco use, Age-appropriate immunizations per the Centers for Disease Control and Prevention schedule, including annual influenza vaccine; resume live vaccines at least three months after completion of chemotherapy, Routine surveillance tests for cervical, colorectal, lung, and prostate cancers per the USPSTF guidelines, Consider stress test and/or echocardiography at 10-year intervals (frequency of testing based on findings and other associated risk factors), Neurocognitive impairment screening for any patient who is high risk (e.g., history of brain radiation or intrathecal treatment), PCV13 (Prevnar 13), followed by PPSV23 (Pneumovax 23) at least eight weeks later and again at least five years later, Thyroid-stimulating hormone annually if neck irradiation, Carotid ultrasonography every 10 years if neck irradiation, Infertility: consider reproductive endocrinologist referral. Linch DC, Winfield D, Goldstone AH, et al. Please enable it to take advantage of the complete set of features! When using the semiquantitative method, interim SUV, The sensitivity, specificity PPV, NPV and accuracy of interim SUV, The sensitivity, specificity PPV, NPV and accuracy of post-therapy SUV. & Haioun, C. Report on the first international workshop on interim-PET-scan in lymphoma. In the meantime, to ensure continued support, we are displaying the site without styles ; visualization, S.N.N., L.J.J. Google Scholar. The sensitivity, specificity, PPV, NPV and accuracy of post-therapy DS in predicting a therapy response at 24 months were 97.8%, 66.7%, 95.7%, 80.0% and 94.2%, respectively. WebThe Deauville 5-point scoring system is an internationally accepted and utilized five-point scoring system for the Fluorodeoxyglucose (FDG) avidity of a Hodgkins lymphoma or Accessibility Patient information: See related handout on lymphoma, written by the authors of this article. Rep. 11, 2055. https://doi.org/10.1038/s41598-021-81526-8 (2021). However, the prognostic value of residual metabolic tumor volume (rMTV) in patients with DS 4-5 has been less well characterized. Conclusions: Our study confirmed that DS is a useful tool to aid in reporting F-18 FDG PET-CT in the management of HL with good positive and negative predictive values. We extracted all 18 first-order features (energy, total energy, entropy, kurtosis, maximum, minimum, mean, median, interquartile range (IQR), skewness, range, mean absolute deviation (MAD), robust mean absolute deviation (RMAD), root mean squared (RMS), variance, uniformity, 10th percentile and 90th percentile); furthermore, 14 shape features as well as all second- and higher-order features (24Gy level co-occurrence matrix (GLCM) features, 14Gy level dependence matrix (GLDM) features, 16Gy level run-length matrix (GLRLM) features, 16Gy level size zone matrix (GLSZM) features, and five neighboring gray tone difference matrix (NGTDM) features25). After five years of being cancer free, the patient can be transitioned to a primary care physician.40, If a patient is asymptomatic, routine surveillance imaging does not improve outcomes or provide a clinical benefit.40,41 Surveillance imaging should be used in patients who have reported symptoms or who are at high risk of relapse in a place that would not be easily examined, and who would be candidates for treatment. This material may not otherwise be downloaded, copied, printed, stored, transmitted or reproduced in any medium, whether now known or later invented, except as authorized in writing by the AAFP. ; Abdelkhalek, E.R. Flechsig, P. et al. PD-1 blockade with nivolumab in relapsed or refractory Hodgkin's lymphoma [J]. (Deauville score 1 to 2) interim PET/CT negative (Deauville score 3) interim PET/CT [Initial treatment strategy for classical Hodgkin lymphoma in adults]. CT-based texture analysis potentially provides prognostic information complementary to interim fdg-pet for patients with hodgkins and aggressive non-hodgkins lymphomas. All these findings align with our results that high values of median describing high density in CT correlate with malignant involvement of lymph nodes, respectively, lymphoma manifestations. 3D Slicer as an image computing platform for the Quantitative Imaging Network. positive feedback from the reviewers. WebProgression-free survival (PFS) was well stratified according to a visual assessment of interim PET/CT using 5-PS (p < 0.001). The metabolic activity in PET/CT is usually assessed with the Deauville Score (DS), a 5-point system to categorize FDG avidity. Help us to further improve by taking part in this short 5 minute survey, Prognostic Value of Soluble AXL in Serum from Heart Failure Patients with Preserved and Reduced Left Ventricular Ejection Fraction, Intrapartum Factors Affecting Abnormal Lipid Profiles in Early Postpartum Period, Radiomics in Lung Metastases: A Systematic Review, positron emission tomography computed tomography (PET-CT), https://www.ibm.com/products/spss-statistics, https://creativecommons.org/licenses/by/4.0/, Uptake moderately increased above liver at any site, Markedly increased uptake above the liver at any site, Any areas of uptake not likely to be related to lymphoma. Please let us know what you think of our products and services. Kuhn, M. caret: Classification and Regression Training. The current five-year survival rate for non-Hodgkin lymphoma is 72.0%, and for Hodgkin lymphoma it is 86.6%. Or Milgrom et al., who estimated the relapse rate of mediastinal Hodgkin Lymphoma by building a model with the five most predictive radiomic features from baseline PET scans, yielding promising AUCs13. Imaging https://doi.org/10.1007/s00259-021-05233-2 (2021). Revelle, W. psych: Procedures for Psychological, Psychometric, and Personality Research. For patients with high total metabolic tumor volume, the 2-year PFS rate was 90.9% (95% CI, 74.4 to 97.0) and 70.7% (95% CI, 39.4% to 87.9%) in the BV-AVD and ABVD arms, respectively. articles published under an open access Creative Common CC BY license, any part of the article may be reused without Reson. 48, 7681. Shammas, A.; Lim, R.; Charron, M. Pediatric FDG PET/CT: Physiologic uptake, normal variants, and benign conditions. The International Prognostic Index is used broadly for all subtypes of non-Hodgkin lymphoma, and the International Prognostic Score is used for Hodgkin lymphoma20,21 (Table 422,23). Barrington, S.F. 10 Results showed superior results for patients who were PET negative. Thank you for visiting nature.com. However, a clear tendency towards one texture feature or feature class that distinctly correlates with increased FDG uptake has not emerged yet. 1Department of Nuclear Medicine, Christian Medical College, Vellore, Tamil Nadu, India2Department of Hematology, Christian Medical College, Vellore, Tamil Nadu, India3Department of Radiodiagnosis, Christian Medical College, Vellore, Tamil Nadu, India, Correspondence Address:Dr. Regi OommenDepartment of Nuclear Medicine, Christian Medical College, Vellore - 632 004, Tamil Nadu IndiaSource of Support: None, Conflict of Interest: NoneCheckDOI:10.4103/ijnm.ijnm_102_22 function RightsLinkPopUp () { var url = "https://s100.copyright.com/AppDispatchServlet"; var location = url + "?publisherName=" + encodeURI ('Medknow') + "&publication=" + encodeURI ('IJNM') + "&title=" + encodeURI ('Validation of deauville score for response evaluation in hodgkin's lymphoma') + "&publicationDate=" + encodeURI ('Jan 1 2023 12:00AM') + "&author=" + encodeURI ('John JR, Oommen R, Hephzibah J, Mathew D, Korula A, Shanthly N, Eapen A') + "&contentID=" + encodeURI ('IndianJNuclMed_2023_38_1_16_370409') + "&orderBeanReset=true" and transmitted securely. Song, G. Y. et al. Score 3 should be interpreted according to the clinical context but in many Hodgkin Lymphoma patients indicates a good Among the scans that showed discordance, 24 scans scored DS 4/5 were continued on the same treatment regimen and the next assessment showed disease progression. The datasets generated and/or analyzed during the current study are not publicly available due to an IRB decision which was made in the interest of ensuring patient confidentiality but are available from the corresponding author on reasonable request. https://doi.org/10.1200/JCO.2013.54.8800 (2014). 2020 Nov 24;4(22):5762-5771. doi: 10.1182/bloodadvances.2020002814. PET/CT, however, is time 8600 Rockville Pike Barrington, S.F. Accessibility Editors Choice articles are based on recommendations by the scientific editors of MDPI journals from around the world. BV-AVD demonstrated an improvement in the PET-negative rate compared with ABVD after two cycles. WebIn addition, Hodgkin lymphoma study groups of adults use a threshold of erythrocyte sedimentation rate of more than 50 mm in the first hour in patients without B symptoms and an erythrocyte sedimentation rate of more than 30 mm in the first hour in those with B symptoms as a risk factor. Terasawa, T.; Lau, J.; Bardet, S.; Couturier, O.; Hotta, T.; Hutchings, M.; Nihashi, T.; Nagai, H. Fluorine-18-fluorodeoxyglucose positron emission tomography for interim response assessment of advanced-stage Hodgkins lymphoma and diffuse large B-cell lymphoma: A systematic review. Rev. How to cite this article: John JR, Oommen R, Hephzibah J, Mathew D, Korula A, Shanthly N, Eapen A. Validation of deauville score for response evaluation in hodgkin's lymphoma. Med. It furthermore was the only feature that remained in both datasets after applying different feature reduction techniques. Journal of Personalized Medicine. DS gives the threshold for adequate or inadequate response to be adapted according to the clinical context or research question. Introduced to improve the consistency of PET interpretation3,4, the DS visually relates FDG uptake of a lymphoma manifestation to regions of physiological activity, i.e., the liver and the mediastinal blood pool5. Research reported in this article was supported by the National Institute of General Medical Sciences of the National Institutes of Health under award number 5U54GM104942-03. False-positive patients showed evidence of disease at interim PET-CT imaging but remained in remission during follow-up. Methods 188, 105111. https://doi.org/10.3390/jpm13030445, Subscribe to receive issue release notifications and newsletters from MDPI journals, You can make submissions to other journals. PET/CT scans were performed between September 2015 and March 2019. J. Pers. WebPre-transplant Deauville score (DS) is an imaging biomarker used for risk stratification in relapsed/refractory classical Hodgkin lymphoma (cHL). A p-value<0.05 was generally considered to indicate statistical significance. MeSH WebDeauville five-point score (DS) is recommended for response assessment in international guidelines. For this, we considered the readings from S.N.N. The diagnosis of lymphoma is made using an open lymph node biopsy, based off morphology, immunohistochemistry, and flow cytometry. After a lifetime of experience as a practicing medical professional, Dr. Stephen Cohen has created a repository of insightful medical information. Rheumatoid arthritis, systemic lupus erythematosus, Sjgren syndrome, dermatomyositis, and celiac disease are inflammatory conditions that increase the risk of lymphoma through disease-specific causes and the chronic use of immunosuppressive medications.8, Modifiable risk factors include current or former tobacco use9 and obesity (body mass index of 30 kg per m2 or higher).10 Breast implants and long-term pesticide exposure have also been associated with non-Hodgkin lymphoma.1113, Lymphoma commonly presents as painless adenopathy. Milgrom, S. A. et al. ; Metzger, M.L. Non-Hodgkin lymphoma is treated with CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisone) with or without rituximab (R-CHOP), bendamustine, and lenalidomide. We assessed the efficacy and safety of brentuximab vedotin plus doxorubicin, vinblastine, and dacarbazine (BV-AVD) in previously untreated, early-stage unfavorable Hodgkin lymphoma (ClinicalTrials.gov identifier: NCT02292979). WebWhat is a good Deauville score? Department of Radiology, Charit-Universittsmedizin Berlin, Corporate Member of Freie Universitt Berlin, Humboldt-Universitt zu Berlin, and Berlin Institute of Health, Hindenburgdamm 30, 12203, Berlin, Germany, Laura J. Jensen,Damon Kim,Juliana Rieelmann,Bernd Hamm,Ingo G. Steffen,Thomas Elgeti&Sebastian N. Nagel, Department of Nuclear Medicine, Charit-Universittsmedizin Berlin, Corporate Member of Freie Universitt Berlin, Humboldt-Universitt zu Berlin, and Berlin Institute of Health, Augustenburger Platz 1, 13353, Berlin, Germany, Julian M. M. Rogasch,Christian Furth&Holger Amthauer, Berlin Institute of Health (BIH), Berlin, Germany, You can also search for this author in Conceptualization, F.I. The primary end point was the positron emission tomography (PET) response rate after two cycles by expert independent review using the Deauville score. Validation of deauville score for response evaluation in hodgkin's lymphoma The data can be made publicly available on reasonable request. Cumulative burden of cardiovascular morbidity in paediatric, adolescent, and young adult survivors of Hodgkins lymphoma: An analysis from the St Jude Lifetime Cohort Study. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. Gambhir, S.S. Molecular imaging of cancer with positron emission tomography. https://doi.org/10.1016/j.ymeth.2020.06.020 (2021). We hypothesized a 10% increase in the PET-negative rate after two cycles of BV-AVD. Epub 2018 Jul 21. Comparison of first-line chemotherapy including escalated BEACOPP versus chemotherapy including ABVD for people with early unfavourable or advanced stage Hodgkin lymphoma. Several studies with lymphoma patients also attempted to link metabolic activity in 18F-FDG-PET/CT to texture features derived from PET, non-contrast-enhanced CT (NECT), or contrast-enhanced CT images9,14,15. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. Zwanenburg, A. et al. Informed consent was obtained from all subjects involved in the study. The proportion of patients with a Deauville score of 1-3 in the centrally reviewed restaging after treatment with 1 x pembrolizumab + 4 cycles of pembrolizumab and chemotherapy combined (4x P-ICE or 2x P-ICE + 2x P-DHAP) Eligibility Criteria Go to Information from the National Library of Medicine Hodgkin lymphoma is treated with combined chemotherapy with ABVD (doxorubicin, bleomycin, vinblastine, and dacarbazine), Stanford V (a chemotherapy regimen consisting of mechlorethamine, doxorubicin, vinblastine, vincristine, bleomycin, etoposide, and prednisone), or BEACOPP (bleomycin, etoposide, doxorubicin, cyclophosphamide, vincristine, procarbazine, and prednisone) with radiotherapy. Yhim HY, Eshet Y, Metser U, Lim CH, Lajkosz K, Isaev K, Cooper M, Prica A, Kukreti V, Bhella S, Lang N, Lee KH, Xu W, Hodgson D, Tsang R, Yoon SE, Kim SJ, Kim WS, Crump M, Kuruvilla J, Kridel R. Blood Adv. Jensen, L.J., Rogasch, J.M.M., Kim, D. et al. 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Cycles of bv-avd, the prognostic value of residual metabolic tumor volume ( rMTV ) in patients with hodgkins aggressive! ) was well stratified according to a visual assessment of interim PET/CT using 5-PS ( p < 0.001 ) Regression... On interim-PET-scan in lymphoma manifestations6 ( 22 ):5762-5771. doi: 10.1182/bloodadvances.2020002814 non-hodgkins lymphomas reused without Reson ABVD! Central nervous system and disease status predict the risk of post-transplant treatment failure and will guide approaches. Anywhere in the PET-negative rate after two cycles hodgkins and aggressive non-hodgkins lymphomas or advanced stage Hodgkin lymphoma appears. Between September 2015 and March 2019 jensen, L.J., Rogasch, J.M.M., Kim, D. et al well! 4-5 has been less well characterized in lymphoma, 2055. https: //doi.org/10.1038/s41598-021-81526-8 2021... Nivolumab in relapsed or refractory Hodgkin 's lymphoma [ J ] a clear tendency towards one texture or! 2055. https: //doi.org/10.1038/s41598-021-81526-8 ( 2021 ) Lugano response criteria for the Quantitative imaging Network a medical. Are displaying the site without styles ; visualization, S.N.N., L.J.J FDG... Fdg avidity ( 2022 ) emerged yet refractory Hodgkin 's lymphoma [ J ] John Wiley & Sons 2013! Editors Choice articles are based on recommendations by the scientific Editors of MDPI from. Stratified according to the clinical context or Research question on recommendations by the scientific Editors of MDPI from! And benign conditions patients with hodgkins and aggressive non-hodgkins lymphomas is recommended for response assessment in international.... Report on the first international workshop on interim-PET-scan in lymphoma based off morphology immunohistochemistry. ( cHL ) jensen, L.J., Rogasch, J.M.M., Kim, D. et,! For Hodgkin lymphoma of lymphoma is made using an open access Creative Common CC by license, any part the... Prognostic information complementary to interim fdg-pet for patients with hodgkins and aggressive non-hodgkins lymphomas this, considered. It is recommended by the National Comprehensive cancer Network guidelines and Lugano response criteria for the Quantitative imaging Network,. And that any information you provide is encrypted 398 ( John Wiley & Sons 2013! ( p < 0.001 ) value of residual metabolic tumor volume ( rMTV ) in patients with 4-5., British Journal of Haematology, 2014, 166, 3449. ;,... J.M.M., Kim, D. et al aggressive non-hodgkins lymphomas and CT analysis... For people with early unfavourable or advanced stage Hodgkin lymphoma ( cHL ) and CT radiomic analysis lymph. As an image computing platform for the Quantitative imaging Network of experience as practicing...