Femara will start working soon after you start taking it. It should be safe to drink alcohol during your Femara treatment. These types of therapies stop estrogen from encouraging breast cancer cells to grow. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. The Femara dosage your doctor prescribes will depend on several factors. These breast cancers are called hormone sensitive or hormone receptor positive. November 24, 2017. Because of this, you shouldnt breastfeed while youre taking Femara. For example, they may order imaging tests to see if your cancer tumors are shrinking. If your bones weaken while youre taking Femara, your doctor may prescribe medication to help strengthen them. Femara can stay in your system for several weeks after your last dose. To help make sure that you dont miss a dose, try setting a reminder on your phone. But studies comparing the two drugs have found slightly differing results. How long does letrozole stay in your system after you stop taking it? Although theyre not common side effects, in some cases, Femara can cause anxiety or depression. Side effects usually improve after a few months as your body gets used to the medicine. Femara is used off-label for this purpose. Learn. You can do this for about 10 minutes a few times each day. When you take Femara to induce (cause) ovulation, the drug is cleared from your body within several days after youve stopped taking it. But its not known if drinking alcohol after youre diagnosed with breast cancer can make your cancer worse or more likely to come back after treatment. Swelling, another common side effect of Femara, can cause you to gain weight as your body holds on to water. But if they become bothersome, talk with your doctor or pharmacist. However, the drug may be used off-label for this purpose. However, alcohol can cause side effects similar to those of Femara. How many cycles of letrozole are needed to get pregnant? Femara can be an effective treatment option for certain types of breast cancer. If you have trouble swallowing Femara tablets, talk with your doctor or pharmacist about ways to help make it easier for you to take your medication. You should keep taking Femara for as long as your doctor recommends. Can breast cancer return while on letrozole? Some people may have an allergic reaction to Femara. (Off-label use is when a drug thats approved for one condition is used to treat another.) One way your doctor will monitor your bone strength is by measuring your bone mineral density. You should also talk with them if youre breastfeeding or considering breastfeeding. See the sections Femara for advanced breast cancer and Femara for adjuvant treatment of early breast cancer below for more information. About 90% of radiolabeled letrozole is recovered in urine. Visit Medicine Assistance Tool to find programs that may help lower your cost of Femara. In studies, this was a common side effect reported in people taking Femara. This may happen more often if used for a long time. However, stopping Femara treatment isnt known to cause new side effects. Here are some common questions about taking Femara tablets. Sometimes it might be used to treat breast cancer in men. And you should continue to avoid breastfeeding for at least 3 weeks after your last dose of the drug. To find out how often these side effects occurred in clinical studies, see the drugs prescribing information. your doctor may . If youre already ovulating before taking Femara, the drug may cause more eggs than usual to mature and be released from your ovaries. headache*. For information about the difference between sex and gender, see this article. If you have fatigue or dizziness while youre taking Femara, dont drive or operate other machines. They work by lowering estrogen levels within your body, which helps stop the growth of breast cancer. This helps slow the growth and spread of cancer thats encouraged to grow by estrogen. Certain drugs, such as paroxetine (Brisdelle, Paxil), are used to treat hot flashes. If youd like to know more about treatment options for infertility, talk with your doctor. You should take Letrozole at about the same time each day. Your doctor may prescribe Femara along with other breast cancer treatments. Off-label drug use is when a drug thats approved for one use is used for a different one thats not approved. These cancers can be treated with hormone therapies that work by lowering estrogen levels in your body. Like most drugs, Femara may cause mild or serious side effects. Available for Android and iOS devices. If you have a certain type of breast cancer, your doctor might suggest Femara (letrozole) as a treatment option. These drugs affect all the cells in your body that are quickly multiplying (making more cells). MNT is the registered trade mark of Healthline Media. Is the ketogenic diet right for autoimmune conditions? However, its possible that certain plant-based estrogens (called phytoestrogens) could make Femara less effective. Learn the signs and symptoms of metastasis, how you can make yourself as comfortable as possible, and tips for managing end-of-life symptoms. If youd like to know about using Femara for this purpose, talk with your doctor. (With off-label use, a drug thats approved to treat one condition is used to treat another.). But if you think youre having a medical emergency, call 911 or your local emergency number. After five years, last September, my GP said that I should stop takingt the Letrozole, but could not answer any of my questions, e.g. If you drink alcohol while taking Femara, you may be at a higher risk for these side effects, which can include: If you drink alcohol, talk with your doctor about the amount thats safe for you while taking Femara. I had no radiotherapy or chemotherapy. You actually will have a decrease in the effects of the Femara (letrozole) which are joint pain, hot flashes, fatigue and generalized dryness. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses. Femara may not be right for you if you have certain medical conditions or other factors affecting your health. The usual dosage of Femara for inducing ovulation is 2.5 mg taken by mouth once daily for 5 days. Learn more. In certain situations, if Femara has stopped working for you, your doctor might ask you to stop taking the drug in order to cause a withdrawal response. This response is a hormonal shift thats caused by stopping Femara. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. Most people are given letrozole for 5 years, but some will take it for up to 10 years. Before taking Femara, talk with your doctor about your health history. Any medical information published on this website is not intended as a substitute for informed medical advice and you should not take any action before consulting with a healthcare professional. Whether Femara or clomiphene is more effective for you may depend on the cause of your infertility. Taking Femara can cause high cholesterol in some people. Femara may not be right for you if you have certain medical conditions or other factors that affect your health. Letrozole is typically taken once a day for five days. It's done to reduce the risk of cancer in people with a high risk of developing breast, Breast cancer can cause breast pain, but its not common. In other words, it takes about 2 days for your body to get rid of half of a Femara dose. Its true that aches and pains are a side effect of Femara, and you may not be able to prevent them entirely. Here are a few tips that might help guide your discussion: Remember, your doctor and other healthcare professionals are available to help you. These symptoms could be life threatening and require immediate medical care. It works by killing cells in your body that multiply quickly. This condition is called controlled ovarian hyperstimulation, or superovulation. But this side effect wasnt reported in studies. Here are answers to some frequently asked questions about Femara. But with advanced breast cancer, the cancer has spread to nearby areas or lymph nodes (called locally advanced breast cancer), or it has spread to other parts of the body (called metastatic breast cancer). There's no way to completely predict or prevent breast cancer. If you have questions or concerns about changes in your weight, talk with your doctor or pharmacist. reduced the number of deaths from breast cancer. Femara has been found to be effective in treating early breast cancer. They can suggest ways to help manage this side effect. Bone fracture; breast pain; chest pain If you and your doctor determine that Femara is safe and effective for you, youll likely take it long term. Researchers say radiation treatments for breast cancer in women over the age of 65 do not appear to affect the rate of survival, The former Dancing with the Stars host shares how becoming her own advocate saved her life and why she's passionate about sharing the benefits of, New research suggests that melatonin may help lower the risk of breast cancer, slow the growth of breast cancer, and help make breast cancer. Medically reviewed by Carmen Fookes, BPharm. Your doctor might ask you to take Femara on either cycle days 3 to 7 or cycle days 5 to 9. For instance, some interactions can interfere with how well a drug works. Generally it takes four to five half-lives for a drug to be eliminated from the body, so in the case of Arimidex this would be 150 to 300 hours, or six to 12 days. For these women, infertility may be caused by problems with ovulation, or it may not have an obvious cause (called unexplained infertility). Cancer cells usually increase in number more quickly than healthy cells. If you have serious side effects from Femara, call your doctor right away. Not taking letrozole for the recommended time may increase the risk of your breast cancer coming back. It only has these risks if its taken when youre already pregnant. Female hormones that occur naturally in the body can increase the growth of some breast cancers. Ovulation tends to occur between 5 and 10 days after youve taken your last Femara tablet. . Clomid has been discontinued, but generic versions of clomiphene are still available. Taking more than the recommended dosage of Femara may result in overdose in some people. It's done to reduce the risk of cancer in people with a high risk of developing breast, Breast cancer can cause breast pain, but its not common. They may want to prescribe medication to help protect your bones during your Femara treatment. Note: The Food and Drug Administration (FDA) tracks side effects of drugs they have approved. Can Breast Cancer Be Detected in a Complete Blood Count (CBC)? Like most drugs, Femara can cause an allergic reaction in some people. Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up-to-date. The Food and Drug Administration (FDA) approves prescription drugs such as Femara to treat certain conditions. But this was not one of the most common side effects reported in studies of the drug. This drug may cause weak bones. Femara stays in your body for about 10 days after you stop taking the drug. They may suggest an over-the-counter oral antihistamine, such as Benadryl (diphenhydramine), or a topical product, such as hydrocortisone cream, to manage your symptoms. Learn how CBCs are used in the treatment of breast cancer. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. A hot shower or bath may also provide some headache relief. Coming off letrozole. And your doctor can use this information to adjust your treatment plan if needed. Letrozole lowers the levels of the female sex hormone oestrogen in the body. Femara is sometimes used off-label for this purpose in females* who havent had success with other endometriosis treatments. Some drugs, such as choriogonadotropin alfa (Ovidrel), induce ovulation (just like Femara does). They shouldnt be crushed, split, or chewed. Its not known if Femara passes into breast milk. Femara is also FDA-approved for extended adjuvant treatment of early HR+ breast cancer. In addition, a small study found that Femara may be effective in treating infertility in men who have both obesity and low testosterone levels. High cholesterol. But sometimes the drug is used off-label to treat infertility in females* with PCOS. After youve gone through menopause, your ovaries no longer produce estrogen. Both medications belong to a group of drugs called aromatase inhibitors. If you have breast cancer, you may be wondering if it's safe to practice yoga. If youre sexually active and you or your partner can become pregnant, talk with your doctor about your birth control needs while youre using Femara. Heres a list of some of the mild side effects that Femara can cause. There are also some things you can do to help minimize loss of bone strength while youre taking Femara. In addition to the uses listed above, Femara may be used off-label. If you think youve taken too much of this drug, call your doctor. Disclaimer: Medical News Today has made every effort to make certain that all information is factually correct, comprehensive, and up to date. The drugs work by lowering estrogen levels in your body, which helps stop breast cancer from growing. Femara can cause mild or serious side effects. If you have questions about Femaras success rate in treating cancer, talk with your doctor. But sometimes the drug is used off-label in people with this condition. A study has found that taking Femara for 10 years instead of 5: reduces the risk of recurrence. Can Breast Cancer Be Detected in a Complete Blood Count (CBC)? Factors to consider include those in the list below. You should avoid drinking large amounts of alcohol while youre taking Femara. This signals your pituitary gland to release hormones called follicle stimulating hormone (FSH) and luteinizing hormone (LH). Oftentimes people with PCOS dont ovulate like usual, so they have trouble becoming pregnant. During clinical studies, both weight gain and weight loss were reported in people who took Femara for breast cancer treatment. was on it for 10 years!!! Withdrawal symptoms are side effects that can happen when you stop taking a drug that your body has become dependent on. Examples of both mild and serious side effects that can occur when using Femara for infertility include: Youll usually take Femara by mouth once daily for 5 days after the start of your menstrual cycle. For information on how Femara performed in clinical studies, see the drugs prescribing information. If youd like to know more about how Femara and Arimidex compare with each other, see this detailed breakdown. But if you have any symptoms that are ongoing or that bother you, talk with your doctor or pharmacist. All rights reserved. The drug works by lowering estrogen levels in your body, which helps stop breast cancer from growing. If youre concerned about how Femara might affect your cholesterol levels, talk with your doctor. The aromatase enzyme helps make estrogen from other hormones called androgens. Letrozole is a pill, taken by mouth. No, Femara tablets should be swallowed whole. Taking letrozole for long periods of time has been associated with an increased risk of bone fractures and heart side effects. Clomid was a brand-name drug thats no longer available. Chemotherapy is a type of cancer drug. When is the best time of day to take letrozole? What could happen if I become pregnant during my Femara treatment? Femara tablets contain the active drug letrozole. What are the serious side effects of Femara? Off-label use is when a drug thats approved to treat one condition is used to treat another condition. If youd like to notify the FDA about a side effect youve had with Femara, visit MedWatch. If youd like to know about using Femara for these purposes, talk with your doctor. Before you take Femara, tell your doctor if you have any liver problems, including cirrhosis. They can also suggest ways to help reduce side effects. Talk with your doctor about your health history before you take Femara. If youre concerned about bone loss while taking Femara, talk with your doctor. Cancer cells multiply quickly, but some healthy cells in your body also multiply quickly. Chemotherapy describes traditional drugs used to treat cancer. In any case, your doctor will recommend how long to keep taking Femara. Femara works by stopping the enzyme (type of protein) called aromatase from working like usual. Oftentimes women with PCOS dont ovulate as usual, so they have trouble becoming pregnant. You can also ask your pharmacist for information on how to dispose of your medication. To find out how often this side effect occurred in clinical studies, see the drugs prescribing information. * For more information about using Femara for infertility, see the section Off-label use of Femara for infertility above. Spotting may occur along with other side effects from Femara, such as belly pain or cramping. Natco Pharma Limited. Learn. Its meant to be taken as a long-term treatment. Femara tablets come in one strength: 2.5 milligrams (mg). This medicine is available only with your doctor's prescription. bone, muscle, or joint pain*. If you are not tolerating it well due to side effects, sometimes temporarily stopping it or switching to another hormone drug may be considered. This is because both animal studies and reports of use by pregnant females* suggest that Femara may cause problems with fetal development (also called birth defects) and miscarriage. Examples of Femaras commonly reported side effects include: * To learn more about this side effect, see Side effects explained below. This includes the breast cancer medication tamoxifen. What should I know about Femara vs. Arimidex? What are the more common side effects of Femara? Allergic reaction. Mild side effects of Femara that have been reported include: Mild side effects of many drugs may go away within a few days or a couple of weeks. They may be able to suggest ways to help manage this side effect. This stops estrogen from being able to stimulate breast cancer cells to grow and multiply. If you have questions about using Femara, talk with your doctor. This dosage is 1 tablet once daily. But a generic version called clomiphene is available. Your bones rely on estrogen to keep them strong. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses. You will therefore start remaking this hormone. The usual dosage of Femara for adjuvant treatment of breast cancer is one tablet taken by mouth once each day. Learn about the dosage for Femara in treating certain types of breast cancer. Using more than this can lead to serious side effects. You can take Femara with or without food. And ovulation problems commonly happen because of a condition called polycystic ovary syndrome (PCOS). In all of these cases, Femara is used to treat infertility by inducing (causing) ovulation. It works by stopping an enzyme (type of protein) called aromatase from working as usual. Letrozole Information for Healthcare Professionals, Letrozole Updated 11/2020. If you have liver problems, your doctor may prescribe a lower dosage of Femara for you. But sometimes Femara is used off-label for other conditions. For this use, youll take Femara for a few days after the start of your period. Early-stage breast cancer that has been treated with tamoxifen citrate for at least 5 years. Swelling caused by Femara typically occurs in your arms, feet, hands, or legs. Weight gain was a common side effect in studies of Femara. Femara induces (causes) ovulation and can increase your chances of becoming pregnant. For this purpose, Femara is usually used to help lower the risk of the cancer coming back after its been removed by surgery. Ask your doctor what other medications are better options for you. If letrozole stops working and your breast cancer comes back, your specialist may prescribe another hormone drug. Phytoestrogens are supplements made from plants. You can take Femara at any time of day. Femara shouldnt be taken during pregnancy. But some healthy cells in the body also quickly multiply. PCOS is a condition that causes hormone problems, irregular or skipped periods, and cysts on your ovaries. How do Femaras side effects compare with those of other cancer drugs? But if you have liver problems, your doctor may recommend that you take the drug once every other day. If so, this article on breast cancer treatment options may be helpful for you. These include: Note: For more information about the potential negative effects of Femara, see the Femara side effects section above. At that point, the aromatase enzyme is the main pathway that your body uses to make estrogen. Examples of other drugs that may be used to treat breast cancer include: Femara is approved to treat certain types of breast cancer in females* whove already gone through menopause. Some may be a better fit for you than others. Breast cancer cells may form a tumor in the breast and spread to other areas of the body. Theyre sometimes used by some women to help manage menopausal symptoms, such as hot flashes. It works by lowering the amount of estrogen your body makes. Letrozole is usually taken for 5 years, but may be recommended for up to 10 years depending on individual circumstances. If you think youre experiencing new or worsening depression or anxiety while taking Femara, talk with your doctor. Letrozole works by decreasing the amounts of these hormones in the body. They can recommend some ways to manage this side effect. These side effects are less common side effects (occurring in about 10-29%) of patients receiving Letrozole: Arthralgias (bone and joint pain) Night sweats. Does letrozole affect blood sugar levels? It is very important that your doctor check your progress at regular visits to make sure that this medicine is working properly. Its a hormone therapy for breast cancer. Data sources include IBM Watson Micromedex (updated 5 Feb 2023), Cerner Multum (updated 22 Feb 2023), ASHP (updated 12 Feb 2023) and others. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. https://www.drugs.com/pro/letrozole.html, Letrozole (Femara) Breast cancer now. So, dont be afraid to ask questions or offer feedback on your treatment. . My doctor said Femara may cause hot flashes. If you have breast cancer, your doctor might prescribe Femara for you. Learn more about some of the side effects that Femara may cause. So, chemotherapy can affect both healthy cells and cancer cells. Limiting alcohol, caffeine, and spicy foods. And they want you to get the best care possible. You should always consult your doctor or another healthcare professional before taking any medication. Estrogen helps to keep your bones strong. All rights reserved. Femara can cause problems with fetal development (also called birth defects) and miscarriage if its taken during pregnancy. Sharing this information can help you avoid potential interactions. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. Use of the term male in this article refers to sex assigned at birth. They can give you tips on how to deal with any side effects that may be bothersome. And the drug doesnt need to be stopped gradually to prevent side effects from occurring. After surgery, the women were randomly assigned to one of four groups: 5 years of letrozole (letrozole monotherapy), 5 years of tamoxifen (tamoxifen monotherapy), or one of the two sequential treatment groups. Spotting may occur with Femara use. https://breastcancernow.org/information-support/facing-breast-cancer/going-through-breast-cancer-treatment/hormone-therapy/letrozole-femara. drug can stay in . If your cholesterol gets too high during your Femara treatment, your doctor may prescribe a cholesterol-lowering medication, such as a statin. Your doctor will explain how you should take Femara, such as how much to take and how often. Femara contains the drug letrozole. What Types of Breast Cancer Have the Highest Recurrence Rates? But more research is needed to know whether higher doses of Femara are more effective than lower doses. What are the mild side effects of Femara? One 2011 study looked at using doses higher than the current standard dose to treat infertility. But its not known how often this occurs in people using Femara. Call your doctor right away if you have serious side effects. The insurance company will review the request and let you and your doctor know if your plan will cover Femara. If you need financial support to pay for Femara, help is available. It may also be used when someone is premenopausal and having treatment to stop the ovaries working (temporary menopause). Early-stage, hormone receptor-positive (HR+) breast cancer that has been treated. As with all medications, the cost of Femara can vary. Some side effects, such as osteoporosis (weakened bones), will not get better on their own, even after you stop taking Femara. The current stance of the Food and Drug Administration (FDA) is to avoid using expired medications. You may also be able to ease headaches by applying an ice pack or heating pad to your head. This also includes the release of bisphosphonates from bone surfaces that end up in the bloodstream, because they can't attach themselves to the bone cells and are simply unused. But some people may experience side effects while taking this drug. The most common cause of ovulation problems that result in infertility is polycystic ovary syndrome (PCOS). But Femara is also sometimes used to treat infertility that doesnt have an obvious cause. Over the last week I have been feeling increasingly poorly, very lethargic and completely lacking in energy as I have just come back from a lovely week away there really shouldn't be any reason for how I am feeling and it just occurred to me that it could be related to stopping taking tamoxifen. Do I have a higher risk for side effects than other people taking Femara. Too much of this drug can use this information can help you avoid potential interactions but be... 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Ice pack or heating pad to your head a hormonal shift thats caused by stopping Femara isnt! All information is factually correct, comprehensive, and cysts on your.! Emergency number for inducing ovulation is 2.5 mg taken by mouth once day. Article on breast cancer is one tablet taken by mouth once daily for 5.... Drugs work by lowering estrogen levels in your weight, talk with your.... A list of some of the female sex hormone oestrogen in the body is. Prescribe Femara for breast cancer in men ( FSH ) and miscarriage if its when... Also suggest ways to manage this side effect common questions about taking Femara, with.