None because of adverse effects on bone. Mar 5, 2009. I know now to separate these two. Would love to meet you if you live anywhere near. If you know where you will be, you could check with health food stores in that area to see which brands they carry, and then I can let you know which of these are being made by reputable, trustworthy companies. Should I introduce the strontium gradually, building up from one pill to two to three over a period of time or should I take one pill three times a day? Dialysis fluids may already contain high concentrations of strontium, so not surprisingly, some dialysis patients are known to have elevated bone strontium concentrations and a high strontium/calcium ratio in bone. In postmenopausal osteoporotic women treated with SR (0.5, 1 and 2 g/day) for 2 years, Sr was dose-dependently deposited into new bone without changes in the degree of mineralization of bone tissue. In Your Bones, 2nd edition, I have provided tables for calcium and magnesium listing commonly eaten food sources and the amount of each mineral provided in a typical serving, hoping to make it easy for you to figure this out. Here is the link: http://orbi.ulg.ac.be/bitstream/2268/7937/1/The%20Effect%20of%20strontium%20ranelate%20on%20the%20risk%20of%20vertebral%20fracture%20in%20women%20with%20postmenopausal%20OP.pdf, Here is his 2002 article which is the one being cited. We would love to work with you further to determine whats causing this and help find a solution. You can learn more about our human clinical trials HERE. And stay gloriously well, The reason 4 hours is recommended is that even if your digestion is slower than normal, you will have absorbed any calcium that was present in your meal or supplements by then. Strontium increases osteoblasts production of osteoid. In all three treatment groups, study participants with above average compliance had significantly greater increases in BMD compared to the losses seen in the two expected-change reference groups. Strontium is a chemical element that naturally found in our body in small amounts. I have to wait 4 hours after meal to take stontium (right) so I have to stay up late or end up getting up in the middle of the night to take strontium. Thank you! So although optimally one would take the strontium 1 hour before breakfast and 3 hours after dinner (on an empty stomach) and the calcium at dinner with food to help absorption and at bedtime (but 3 hours after the strontium) to help sleep. Strontium ranelate slows down the cells that break down bone. Please keep me posted on how you are doing. Osteo-cise: Strong Bones for Life: Protocol for a Community-based Randomised Controlled Trial of a Multi-modal Exercise and Osteoporosis Education Program for Older Adults at Risk of Falls and Fractures.BMC Musculoskelet Disord. D3 and K2 must be in balance. It really helped put my mind at ease. My husband is Dr. Joseph Pizzorno. Start now. However, because you have significant bone loss (-2.45 in your left hip), you need to avail yourself of all natural, safe means of restoring the health of your bones. The end result was that more calcium (Ca2+) was deposited in AlgaeCal treated cells (2.0-fold more than controls, 1.0-fold more than calcium carbonate, and 4.0-fold more than calcium citrate-treated cells). We dont recommend taking another calcium supplement with AlgaeCal. I find my body has more energy, sleeps better and just feels better when I minimize my grain intake. If your bones were M&Ms, cortical bone would be the outer candy shell and trabecular bone the soft chocolate center. That means I am getting 250 mg of calcium. I just started taking AlgaeCal Plus and Strontium Citrate. I believe it is a foundational health supplement for everyone not only postmenopausal women. I will be having a DEXA scan next month to determine if the strontium citrate and algae cal plus that I presently take have been effective in increasing my bone density. I have read your book,Your Bones and not really found a specific answer to this question . If you have reason to believe YOUR thyroid function might be affected (e.g., you have had other issues with thyroid function prior or currently), why not use a lower dose of strontium for yourself and check its efficacy in YOU after 3-6 months? RE strontium at a lower dose I agree with you, and so does Dr. Wright. Mary. I will be 69 this year, and took my share of the old kind of Estrogen. Also, sometimes crystals can form and deposit in a joint a thumb joint version of gout. I have two questions..one regarding your recommended daily dosage for strontium and the second regarding your recommended daily dosage for Vitamin K4. Though there was no noticeable adverse effect it was only 41 mg day-1, maybe long term supplementation at 16.6 times that much could pose an issue. abkeeffdkekd. You want to identify and eliminate as fully as possible ALL other sources of inflammation in your diet, environment and lifestyle. The amounts of the other forms of vitamin K (K1 and MK-4) are so tiny, they will have little impact on activation of Gla-proteins. just let me know. I typically spend 4+ hours each day reading the breaking research, and this is how I discovered AlgaeCal a little over 18 months ago now. While the human skeleton is composed of approximately 80% cortical and 20% trabecular bone, it has been observed that Sr absorption is different between these two types of bone, with trabecular bone showing a higher Sr concentration than cortical bone, likely due to the fact that cortical bone has a slower turnover rate compared to trabecular bone. Calcium will be pulled out of our bones when our pH is to acidic to help restore pH levels to a more alkaline state. One study is 2004 and one is 2012 and rely on use of the ranelate version of strontium not citrate. I would be interested to learn of any further research on Lactoferrin and its positive effects on bone building. I think the ratio should be 2/3 as much magnesium as calcium rather than 1/2 as much and this is what I take myself 2/3 as much magnesium as calcium. I urge anyone taking ANY type of prescription medication to check on the adverse effects of the drug and the symptoms it produces. . pam. Why Take Erection Pills On Empty Stomach At the beginning, it must penis enlarging products be adapted to capitalists, otherwise it would be impossible to break through the constraints of thick hard penis pills traditional moral concepts. The truth is, strontium does weigh much more than calcium, and its mass does impact DEXA readingsbut only a little. The doses ranged from 100 to 750 mg/kg per day of strontium ranelate, corresponding to 34255 mg/kg per day of Sr21. . Wed encourage you to discuss these points with your primary care physician. used a more aggressive exercise program. You dont have to be eating a full meal; a small snack will be sufficient. The drug makes your bones stronger and lowers your chances of getting fractures. 2016 Sep;43(9):1105-7. I then came across Dr. Keith Scott Mumbys article which said 170 mg is more effective. Epub 2016 Oct 21. Within 3 hours, you will have digested the yogurt and absorbed the calcium in it. https://www.ncbi.nlm.nih.gov/pubmed/22172139. So its important that you take the two minerals at least 2 hours apart. Thank you for your wonderful advice. Im sorry to hear about sisters! There are only 360 mg of calcium in the two tablets listed as serving size. I will look into recommendations for a good endocrinologist in Phoenix. It will definitely cause inflammation in your body and as you know if you have read Your Bones anything that provokes chronic inflammation activates osteoclasts excessively and causes bone loss. Again, no adverse effects were reported nor were any seen in the comprehensive blood chemistry tests run on study participants. When our nerves send a muscle cell a signal to fire, the muscle cell responds by allowing a flood of calcium to enter, and it is calciums entry into the muscle cell that initiates the cascade of reactions that result in making the muscle cell contract. Please give Strontium Boost a try. And so are my gluten-free sourdough breads you can find the recipes here (add link). You should especially avoid eating fruits with tough fibers like guava and oranges early morning. Let me know how you do. The only issue I have ever heard even anecdotally mentioned re MK-7 is that one woman wrote me that it gave her so much energy, she had trouble sleeping; she has to use MK-4, which clears out of the body much more rapidly than MK-7, for which reason, an effective dose of MK-4 is 45 milligrams per day! What is an adequate amount is for post-menopausal women to take? I will run a DXA on Monday . Lara Thank you so much for your book and the information you supply to women that need all the help the can get. Re the high blood calcium, my first thought would be that you need more vitamin K, specifically, K2 as MK-7. Am J Public Health. Hi Lara. Strontium does not cause hair loss, so we need to look elsewhere to determine why that is occurring. Actually, the K1 will have no impact on Gla protein activation it will be used for clotting factors and also has anti-inflammatory effects (so good to help prevent excessive activation of osteoclasts, which is triggered by chronic inflammation). Even taking 3 tablets only increases the calcium intake to 540 mg. Also can you tell me where I can buy your bookThank you so very much. Ive read that estrogens might decrease how fast the body gets rid of strontium and cause side effects. Since everyones physiology is unique, its safest to start out with 25 mg and gradually increase up to 50 mg over a couple of months. The intriguing results show bone strontium incorporation and retention follow a pattern, suggesting strontium levels, at least in the ankle, do not plateau within two to three years and will continue to increase over time, as an individual takes strontium supplements. What you want to do is take your strontium at a time of day when you are NOT consuming any calcium. (I had read Christopher C. Barr, and followed his advise no calcium, only magnesium and silica). Ranelic acid was created to make it patentable. Do you take a multivitamin as well? In the U.S., Your Bones was approved by our library book review system and is available in our public libraries as well. MATERIALS AND METHODS: The intestinal permeabilities of 14 drugs and three drug-like compounds with different absorption mechanisms in rat and human jejunum were determined by in situ intestinal perfusion. I needs to spend some time learning more or working out more. If you havent read it, please consider doing so. If you cannot tolerate dairy, then look for yogurt made from organic soybeans or coconut. PMID: 11683526: Animal studies using strontium chloride found that within 4 weeks, strontium increased the number of bone-forming sites, trabecular bone formation and bone volume in vertebrae and alveolar bone (the jawbone), and reduced the number of osteoclasts present. In conclusion, the different studies performed on bone samples from monkeys and humans treated with various doses of SR showed that Sr was heterogeneously distributed between new and old bone but in a dose-dependent manner without alteration of the crystal characteristics and the degree of mineralization of bone tissue, even after long-term administration of often high doses of SR (the highest therapeutic dose used in humans is 4-fold lower than the lowest experimental dose administered to monkeys). Secondly, Strontium Boost is strontium citrate. Some researcher believe that calcium and magnesium, being 2 cation molecules, should be taken separately for optimal absorption of both minerals. Hello, I am 69 years old and my dexa scan says I have osteoporosis. Re what I eat for lunch typically, I have lots of vegetables (raw salads e.g.,greens, cole slaw, cucumber salad, lightly steamed vegetables like broccoli, carrots, cauliflower and/or roasted vegetables like beets, squash, potatoes, yams, etc.). Hello! First of all, 750 mg/d is an excessively high dose higher than that used in all the research Ive seen on strontium. Previous GFR readings over the past 10 years have been as low as 56 but seem to hover in the high 50s to very low 60s. PMID: 27684387. 2012 Oct;33(10):1277-84. doi: 10.1038/aps.2012.83. These are really great questions, and I am so sorry to hear of what you are going through. As you know, bacteria, both by their very presence and also in reaction to the byproducts of their own metabolism, provoke an inflammatory response by the bodys immune system. Thanks, Hi sml, If you take 1,000 mg of calcium a day, split it into two or more doses over the day. So, each capsule provides 226 mg of strontium. Thanks. The results confirm both theoretically and experimentally that the effect of bone strontium on BMD measurements is different for different DXA systems. https://www.ncbi.nlm.nih.gov/pubmed/20699129. Youre so welcome! It is possible, by the way, to check strontium levels in bone heres a recent paper in which they did just that (abstract below) but I dont think this new X-ray fluorescence 1-125 based system is yet available to us normal folk outside the rarefied realm of research studies. AlgaeCal Plus provides the key nutrients our bones must have to maintain themselves, regardless of our age, and in amounts shown in the research to be sufficient for most people. Ammann P, Shen V, Robin B, Mauras Y, Bonjour JP, Rizzoli R. Service of Bone Diseases, World Health Organization Collaborating Center for Osteoporosis Prevention, Geneva 14 CH-1211, Switzerland. In female rats treated with strontium ranelate over 2 years, dose-dependent increases of bone strength and bone mass of the vertebral body (containing a large proportion of trabecular bone) and of the midshaft femur (containing mainly cortical bone) were detected without change in bone stiffness. Aquamin has done one absorption study where PTH response is measured. Thus, I am unable to read the paper in which 170 mg of strontium is said to be more effective, so I do not know what was done and cannot give you more helpful feedback on this. My hair started falling out and I read it might be the strontium so I cut back to 380 strontium. The most recently published human study that discusses strontiums incorporation into trabecular versus cortical bone is Moise H, Chettle DR, Pejovi-Mili A. Given all this, its surprising that strontium ranelate continues to be authorized and prescribed in Europe, despite the French pharmacoeconomic committees judgment in 2014 that strontium ranelate had insufficient medical benefit, and a highly unfavorable opinion on the use of the drug issued by the European Pharmacovigilance committee in 2015. I recently had a DEXA scan which showed some improvement in my bone density. Re #2, following are the citations of a few of these papers (all are available on PubMed) with my italics added for emphasis and my comments on the relevant text: Regarding boron, this trace mineral is also definitely needed. However, since I have been taking strontium citrate for about 3 1/2 4 years I have decided to take only 1/2 the SC dosage (340 mg) because I am not sure if there are any long term negative effects from using SC indefinitely. I stopped taking for a few days& the diarrhea stopped. Howdy! Heres just one of many medical journal articles discussing the benefits of regular weight bearing exercise on preventing falls: Robitaille Y, Laforest S, Fournier M, et al. I promise you, you can completely restore the full health of your bones! Answer (1 of 3): It is very important to take your levothyroxine at least 30-60 minutes before breakfast, on an empty stomach. Recently I have cut back on my dosage of strontium citrate from 680 mg daily to 1 tablet of 340 mg daily. Hi Lara, I am recently diagnosed with Oestopenea, I live in a part of world with poor health facilities and women health are completely neglected. In other words, for every 10 calcium ions your bones absorb, they will absorb less than 1 strontium ion. Take your strontium before bedtime at night. If you have a copy of Your Bones, please read the sections on both calcium and magnesium. Heres the 2004 paper that came up when I ran a PubMed search for Meunier PJ: Med Sci (Paris). I am a medical writer and have been a member of the AMWA (American Medical Writers Association) and have been writing medical journal articles and medical books for doctors and for the public for 30+ years now, so I am very well educated, and I also work with my husband, but I am not a doctor. As a result, a treatment with Strontium should not induce any alteration of bone mineral.. Further increases occurred within an interval of 90-180 days, with the most recent, after 800 days, at the finger and ankle being 7 and 15 times higher than the initial baseline reading. I just yesterday heard Cees Vermeeer one of the leading researchers in the vitamin K2 field for more than 30 years now give a webinar in which he discussed the most recent study his team has run, which involved more than 16,000 people and lasted more than 3 years. It has now been 3 weeks and I have received no response by any of the authors. Also take Synthroid (77). Remember, the women were not taking calcium supplements, just getting their calcium via the foods in their normal diet, so not restricting the time during the day when they took their strontium citrate also seems reasonable. I take a PPI for stomach ulcers which is time release and works for 24 hours. For more information, feel free to give our Bone Health Consultants a call at 1-800-820-0184 , You are a big advocate of strontium citrate. PMID: 21241838, Schofer MD, Block JE, Aigner J, Schmelz A. I worry about blood clots. And 340 mg/d is the amount of Strontium Boost I will continue to take to maintain that condition. Strontium ranelate: dose-dependent effects in established I have written some blogs for them discussing research related to bone health and have been compensated for this e.g., my blog on the issues surrounding strontium or the blog I recently wrote on the potential dangers of fluoride. I have read some articles about using a lower dose of strontium. Re lactoferrin, it looks quite promising. PMID: 25293384 PMCID: PMC4187454. 2012 Mar;41(3):92-9.PMID: 22396920) Calcium is also required for our nerves and muscles (including our cardiac muscle, the heart) to function properly. Magnesium (as Oxide) 197mg That makes sense about the calcium dosage; the online label didnt say how often to take it. Our kidneys eliminate strontium far more quickly than calcium: three times as much strontium is lost in urine compared to calcium. Delighted you are finding the information in Your Bones annd here on AlgaeCals blog helpful. The only red flag I received was for Strontium. . You may need to take iron with a small amount of food to avoid this problem. AlgaeCal Plus can definitely be taken without the Strontium Boost, however, our clinical studies have shown triple the results when both are taken! I like it when people reach the same conclusions I have. A creatinine clearance rate of 60-89 indicates the initial stage of kidney disease. Radioactive strontium isotopes (85Sr and 89 Sr) are also used as delivery agents for chemotherapy drugs and for diagnostic purposes in kinetic studies. One caveat here if you eat tuna PLEASE purchase tuna that has been checked for mercury content! Association between DHEAS and bone loss in postmenopausal women: a 15-year longitudinal population-based study. I think arrowsps suggestion that for SCW strontium absorption may take more time than is average so abnormally high levels might have still been present in her blood when the test was run is certainly worth considering. Its the dream team for building bone density thats noticeable via DEXA scan just six months after starting daily use. I hope this information is helpful to you and encourages you to give AlgaeCal a try. I dont eat dairy or Night Shade vegetables (Im on an anti-inflammatory diet which has helped both the beginnings of arthritis and COPD diagnoses about 4-5 years ago). Youll understand why strontium works as it does when you read the list of strontiums bone-building effects on both osteoblasts and osteoclasts. I know you focus on strontium supplementation but should I be concerned if I have too much strontium? BE WELL! Sounds like you are doing lots of good things for not only your bones, but your health overall. Great! Some supplements and lifestyle modification can help relieve reflux. Please advise soonest, if it is okay for me to take the Algae Plus without the strontium as I am suffering of thrombocytopenia as well. Long-term studies in rats confirmed pronounced dose-related increments in trabecular bone volume, mineralised bone volume, osteoblastic surface, and a reduction in osteoclast number, but osteoid thickness was not affected., Dahl SG, Allain P, Marie PJ, et al. Depending on the amount of food consumed, the sensation may take hours to return. OK to your questions: I have hyponatremia. Because doctors do not tell you the truth when it comes to improving your bone density. Inspired by her family history of osteoporosis and her own battle with low bone density, Lara Pizzorno has devoted more than thirty years to researching how to prevent bone loss and restore bone health. However, even adding 1 Strontium at bedtime causes the loose bowels and squeezing discomfort to return. Pilates exercises with an instructor who has been trained to work specifically with people with bone loss may be very helpful for you. I expect it may not be possible for you to ask for strontium in its natural form of strontium citrate, rather than the drug form, strontium ranelate? They affect the skin, liver and immune system precisely the organ systems where these ADRs caused by ranelic acid occur. Hope this helps, Lara. I dont know what type of exercise regimen you follow, but in both exercises and your daily activities, it is very important NOT to do movements that flex your spine forward into a big C curve. The latest science shows your result may be overstated by 8.5% 11.2%. There are currently three such tests available: NTx, CTX and Dpd. Your email address will not be published. Or do you half that too? Ridiculous rumors spread like wild fire, and I all too often hear from people frightened by the latest rumor scare tactics. Alternatively, some foods can interact with . The reason for this is that the EPA/DHA in Triple Power will gradually replace the pro-inflammatory omega-6 (arachidonic acid) in your cell membranes, and specifically in your joint capsule, so your inflammation level will drop and your joint will be able to begin to repair. Curr Osteoporos Rep. 2006 Mar;4(1):34-9. doi: 10.1007/s11914-006-0013-6. Also, your answer gives me peace of mind in deciding to half my dose of strontium citrate. Hi Peter, Strange. My results have convinced me that AlgaeCal is the calcium supplement I am going to continue to use. I find if I am good about taking my vitamin A and Triple Power, I am rarely sore the next day. Three years ago I had my first DEXA scan and the results were normal (hurray, and thank you AlgaeCal!!). You were correct. Farah, Hi Farah, Thanks for the compliment, very glad my article set your mind at ease regarding the use of strontium citrate to safely help you rebuild healthy bones. Seemingly in Europe every time they move wheat from country to country they spray it with insecticide and of course you can imagine what that does to your system. First thing in the morning is best because if taken to late at night you might have problems falling asleep, due to the altering serotin levels. Thank you for magnificent info I was in search of this info for Hi Lynn, I also use their strontium boost product its less expensive for me since I order 6 months of both at a time and get a good discount on the price, and also dont have to think about having to order something more than twice a year. Also read the labels on the processed foods you eat anything that comes in a can, box or plastic package and has a bunch of chemicals added. We just need to keep anything high in calcium (100 mg or more) a minimum 2 hours away from strontium to avoid an absorption interaction. 6. Should the Calcium supplement be taken morning then, evening for better absorption or is the schedule of Strontium Calcium Calcium, with the. How is your digestion otherwise? Again, however, what you (and each of us) is concerned about is YOUR personal potential for adverse effect. Magnesium (as Phosphate) 21mg Re wheat I have just wrapped up my review of Alessio Fassanos lecture on wheat/gluten-containing grains at the Institute for Functional Medicines 2013 symposium. Int J Clin Oncol. You can get this small amount of MK-4 from foods though a list of food sources is in my vit K2 review on LMR. Both the strontium and thecalcium supplements are absorbed in our gastrointestinal tracts using the same mechanism. The reasons for this are that failing kidneys lose their ability to: (I realize you have read these papers, but wanted to include a couple of quotes from them for others who may be interested and have not.) I can only have a bone density test done every two to three years. Maybe animal studies? My only consideration would be the quality control level of the company selling the product. FYI one tablespoon of ground whole flaxseed is going to provide you with about 25.5 milligrams of calcium. Finally, strontium has been linked to an increased risk for dangerous blood clots, called venous thromboembolism (VTE), blood clots in the lungs (pulmonary thromboembolism) and heart attacks. PubMed, Web of Science, Scopus, HighWire and Google scholar) for all the articles by Meunier and found over 150 articles relating to strontium in which he was involved. These results indicate that all benefitted, although to varying degrees and also that both trabecular and cortical bone strontium levels do continue to slowly increase at both sites after 4 years of strontium citrate intake. Therapeutically, radioactive strontium is used to treat metastatic cancer but can damage bone marrow and act as a potential carcinogen itself at high doses. Thanks for the info on Vitamin D. Thats interesting that it was advised to only state 100%, but in some ways isnt surprising. Weve visited a couple of times we have friends at Southern Cross University and my husband, Dr. Joe Pizzorno, has lectured there. The plaque build up in your carotid arteries definitely suggests you need more K2! I am currently taking AlgaeCal and Strontium Boost daily, for 2 years now. These natural pills contain pure magnesium, strontium to help max boost absorption rates and open a new chapter so you can continue to grow and restore your . From: What to take to your Doctor about Strontium Citrate: Strontium Supplementation and DEXA Scan Readings AlgaeCal has a US FDA issued NDIN (dietary ingredient notification) / Aquamin has no NDIN, is not legally for sale in USA Indeed the 500 mg of strontium ranelate (used in Meunier study) is equivalent to 170 mg of elemental strontium, and 2 grams of the compound equates to 680 mg of strontium. http://pstvet.com/pst/clinicalnew.htm and http://pst-global.com/images/1-22.pdf. Another potentially deadly side-effect of taking strontium ranelate is DRESS syndrome. And taking a half dose of AlgaeCals calcium supplement should also be quite safe. I did take my actual calcium, Vit D, Magnesium, B vitamins, etclater in the day as well. One very important factor to consider is vitamin A. Vitamin A is the key nutrient required for immune tolerance (vitamin A is involved in causing the immune system to produce regulatory T cells of the IL-10 strain, which help tune down and resolve inflammation), and many of us are not getting adequate vitamin A, which also works in partnership with vitamin D and should be consumed in comparable amounts for the optimal benefits derived from both nutrients. So, if your patient achieves a 5% increase in BMD in their lumbar spine, when you factor out strontiums BMD overestimation, on average thats still a 4.5% increase. You are now my go-to reference for bone health. thank you For much more on these issues, please listen to my #AskLara on the AlgaeCal Community discussing the differences between HRT and BHRT, also 2 other #AskLara discussing testing that should be done when using BHRT (NO ONE should use HRT!). If I do continue on it, will this contribute to a worsening of my existing kidney disease? Going to provide you with about 25.5 milligrams of calcium in it believe calcium. Have to be eating a full meal ; a small amount of strontium the! Break down bone the high blood calcium, vit D, magnesium, vitamins! Mg/Kg per day of strontium ranelate, corresponding to 34255 mg/kg per of. Our bones when our pH is to acidic to help restore pH levels to a worsening of my existing disease. The help the can get this small amount of food consumed, the sensation take... 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