Dr. Morgan concluded her story with: Be your pets advocate. My 14 year old Border Collie has had trouble with parasitic medicines since she was a puppy. They were extremely helpful people. Not that I want to complicate things; its really just a case of sacrificing convenience on the altar of necessity. (357 reviews) Simparica. Its safe for pregnant/nursing mother dogs and puppies as young as eight week. Though I already mentioned Nexgard as being included in the FDA statement, Im dealing with it separately because it is such a well-known product. Grupo de perros 1x, 3x y 5x veces la dosis. Description: Simparica TRIO is a monthly chewable tablet that protects your dog against heartworm disease, five types of ticks, fleas, roundworms and hookworms. However, while Panacur C can be used to treat Giardia, it is probably not enough to take care of it alone depending on its severity, and will work best in combination with an antibiotic. Zoetis (Simparica, Revolution Plus): 888-963-8471; If you prefer to report directly to the FDA, . What do you know about this? Second, Id like to ask a question if you dont mind. The product was well tolerated in dogs with a deficient multidrug-resistance-protein 1 (MDR1 -/-). Still be careful to monitor for skin reaction if you try the Frontline Gold, too. All Rights Reserved. Thank you for the warning. If your Collie doesnt play like that, you should be fine. I looked up potential side effects for the new pill, and sure enough, the product info for the pain medication specifically advised that it should not be taken with blood pressure medication. Simparica comes as flavored, chewable tablets and is available in a variety of sizes: 5, 10, 20, 40, 80, and 120 mg. 6. My question is this Is it the heartworm component of the combination heartworm/flea pill or is it the flea component? Safety. This can provoke neurological toxicity in MDR1 mutant dogs even at standard dosage, as it is well known for drugs like ivermectin . No empty lots of overgrown vegetation around and tidy lawns so do you think tick prevention is really necessary? Dogs, 6 Month Supply removed from the wishlist. That doesnt mean I would guarantee it will be safe for every dog, but unfortunately its not really possible to say anything will be completely, 100% risk-free. I am currently fostering 3 rescued puppy mill border collie females with sarcoptic mange. Capstar can be used with heartworm products and some other flea products (see link above for compatibility chart), and it can be given to pregnant or nursing dogs and cats, and even puppies or kittens that are older than 4 weeks or heavier than 2 pounds. After 24 hours, it is considered waterproof and a bath, while alleviating some effects, will not offer as much relief. I gave Advantage Multi a caution rating (mostly due to the negative effects that can occur if its ingested) and Advantage II a safe rating. Based on Zodiacs ingredients, it should be relatively safe for an Aussie although it may be a bit harsher than some others as the label indicates it should only be used on dogs 6 months or older. We took her to a vet who is very experienced with collies (she helps with a rescue) and has assured me that Simpirica Trio is safe. We recently switched our dogs to a new product called Simparica Trio. This product has the distinction of repelling and killing fleas (at all life stages), ticks, lice, mosquitoes, and even repelling biting flies. Excellent research and well written article! Our dogs deserve the best. FREE delivery Tue, Mar 7. A couple people claimed that the trick to getting them to work well is to use a slicker brush to part the fur of the mane, to ensure the collar is close to the skin for best effect. Also I live in Michigan just outside Detroit so his walks consist of concrete sidewalks and no real wildlife to come across. The emphasis of this article will continue to be on safety, though I have no doubt as to the efficacy of certain pest preventives over others. I would appreciate your comments on Advocate. ? In light of this, Im categorizing all three of these oral flea/tick protection chews as use with caution, although in fairness I must note that a link between the occurrences and seizure-prone or MDR1 dogs has not been identified. The vet said at first that was not possible and checked with their pharmaceutical representative who said that was not possible. Just checking in to see how you and your pup are doing and if you ended up using Seresto collars or not. We may earn a small commission if you make a purchase through an affiliate link in this article. Also, it might be helpful for you to go to the Quick Nav box near the top of the article and just read or reread the intro and the sections on heartworm meds and oral flea/tick meds if you want a deeper understanding of this topic. Hypersensitivity reactions may occur in some dogs when ProHeart is administered alone . Sarolaner, sold under the brand name Simparica, is an ectoparasiticide veterinary medication for the treatment of flea and tick infestations in dogs. Thankfully he recovered but my vet tells me Interceptor Plus is safe and he must have ingested something on his walk. All the available heartworm medications on the market are a variation of what is known clinically as a ML (macrocyclic lactone) compound. I may even try Advantix on Freckles, my Aussie mix, since she is less prone to skin irritation and Advantix seems to be better tolerated than Seresto when it comes to that. Although there is an overwhelming amount of information related to unsafe drugs and MDR1 Mutant dogs, it was difficult to find information on safe parasitic drugs to say the least. I tried to review a variety of the most well-known parasite protection products out there, but if I left out any you are curious about, leave a comment below! While I dont believe it be quite as effective as the label says it is though that might have something to do with living in pest-ridden Florida I do find it to be very helpful. I will try to find the article again, I stupidly didnt bookmark it. . Both of those products should definitely be more effective than the Frontline Plus. If youre someone who lives in a tick-prone area or likes to take your dogs on woodland rambles (like me), this is a letdown. I also have a 5 month Aussie who the current vet has on Bravecto 1-month and TriHeart. Im not a veterinarian and would of course recommend that you consult with yours, but I do think that dogs vary individually (just like people) and can react differently to certain medications. Wondercide sounds like an excellent place to start as far as flea and tick prevention, and I hope it will be effective against mosquitoes, too. It probably is the safest as it is aimed only at preventing heartworm. Product Description. Because I am only one person, the medication is relatively new, and it has active ingredients that are the same as more well-known medications that have been known to cause issues for many dogs, I didnt feel that I could give it an entirely glowing recommendation. Rev. If it is, it could possibly double as heartworm prevention, although I would highly recommend getting more frequent heartworm tests done (perhaps 3-4 times per year, or as often as your vet recommends) to make sure no mosquitoes managed to infect your dog with heartworms. ? new post updates in monthly email newsletters. Matching game, word search puzzle, and hangman also available. Positive feedback keeps me writing! Roxie has never been tested, but she is Dashs niece so probably also mutant/normal if I were to guess. A dog on Heartgard may heaven forbid, but dogs can be gross eat the feces of an animal who was given an Ivermectin-based medication. (Some of the links lead to peer-reviewed scientific articles, so have fun with those if you want the bare, dusty facts.). Dash is MDR1 mutant/normal. I understand that most dogs are not having negative side effects as a result of using Bravecto, Nexgard, or Simparica but enough dogs are. Options: 3 flavors. Hi Vicki, This is typically due to a specific genetic mutation (MDR1) that makes them less able to tolerate high doses of ivermectin. You might want to look at the information on Nexgard. Id like to have a Smooth Collie in the future. Our are both indoors and outdoors. Thats so sad about your cats I had no idea they could also carry a gene that makes them sensitive to certain medications! Background: The efficacy and safety of a novel isoxazoline compound, sarolaner (Simparica , Zoetis) and spinosad (Comfortis , Elanco) as a positive control were evaluated for the treatment and control of natural flea infestations on dogs in two randomised, blinded, multi-centric clinical trials conducted in 11 veterinary clinics in northeastern and southeastern states of Australia. The FDA issued an alert to owners and veterinarians and said it was requiring clearer labels on the products. He said he himself uses Seresto collars on his Australian Shepherds, but that in his experience the collars tend to last 6 months for his fluffballs, not 8. Most pet parents give heartworm medications in conjunction with flea & tick medications, so Id have given Nexgard a caution label even before the FDA warning came out. I just picked out a beautiful tri color rough collie this morning! My take on this medicine is, while I have to label it as technically safe, I wont recommend it as one of the finest options. Simparica is administered once a month as a flavored chewable. Sarolaner had been approved in 2016 to treat flea and ticks, moxidectin . The flavored, chewable tablets were consumed . I recently saw the USA Today headline (I get notifications on my phone) about Seresto collars and made a mental note to read it later and update this article if need be then promptly forgot about it! In effect, its like a canine-safe version of Ibuprofen, and it really did help her. In my opinion, this spray is great combined with anything since it has repellent properties and smells delightful. Thats a rough situation, and Im sorry you and your pup are going through this. Simparica Trio is the first and only product that combines sarolaner, moxidectin, and pyrantel in one simple-to-give chewable-for protection against heartworm disease, ticks & fleas, roundworms & hookworms.. One chewable tablet provides month-long protection for all dogs over 8 weeks old and weighing 2.8 pounds or more. However, not all MLs are created equal, and some are safer than others. Use of those drugs can cause serious neurological illness or death. The FDA noted that these products continue to be safe and effective for the majority of animals. Simparica Trio can be used from 8 weeks of age in animals over 1.25kg. Though water resistant, frequent bathing or swimming (once a month or more) will reduce the collars effective time to 5 months or less. My veterinarian, knowing of Yoshis MDR1 gene status, specifically recommended Credelio as a safe option because she was suffering from a terrible flea allergy. This May he tested positive again, but the vet thinks it could be residual from when he had it before. This is typically due to a specific genetic mutation (MDR1) that makes them less able to tolerate high doses of ivermectin. Specifically, does it contain any form of -mectin (i.e. It covers fleas, ticks, and heart worms. Giardia can be passed to and cause diarrhea in humans. I have two Rough Collies who are MDR1 carriers and an Aussie mix, so I have a vested interest in everything Ive researched. For those of you who want proof or a more in-depth explanation of whyIve given each medicine its label, feel free to read the commentary under each product and even follow the embedded links for further reading. Basically, while the FDA has not pulled these drugs from the market, it has asked the product manufacturers to add precautions to their labels while it continues to monitor information submitted by veterinarians, the companies themselves, and individual product users. For anyone who prefers to use organic instead of chemical products or would like a repellent in addition to what you are already using, this is the flea and tick spray for you! It was the amount of ticks Ive been having to remove that lead me to your article! GSD is an abbreviation for German Shepherd Dog , Thankyou so much for your articleso much great infoI have a 7 month mini Aussieon Symparticabut not feeling good about itshe hasnt been tested for MRD1 but I know I have to change it upthankyou again , Youre very welcome, and good luck with your pup! It is approved for use on puppies at least 3 pounds in weight and 7 weeks of age, cats, and even ferrets. I took them both to the vet for minor problems, a sore ear and a minor abscess. So, what do you think of Parastar Plus? Why does Credelio listed as with a CAUTION if you use it and it has so far had minor incidence of side effects? We often go on walks in the woods. In the meantime, no need to give heartworm meds if its still snowy where you are, so youve got some time to figure out what to do before the mosquitoes become active again! If you still decide to give this collar a try, the takeaway here is to not put it on your dog and forget about it. User warnings Wash hands after handling the product. For dogs who have a case of mange or ear mites, the treatment can involve topical applications of compounds containing (you guessed it) Ivermectin. Thank you so much for writing this article and for the information you provided. Unacceptable for me) He is MDR1 clear. The neurological problems tied to Simparica scare the shit out . 5 types of ticks (the only proven chewable for most type of ticks elimination) The study also established safety: Simparica Trio was well tolerated by the dogs, even in the presence of concomitant medications, with adverse effects mild and minimally occurring. She immediately throws up the medicine, and the Soresto collar left her skin raw underneath (I didnt notice until I took it off to bathe her). I read that you you used this combination with success. I grew up in Michigan, and we always discontinued pest products during the cold season. I have two beautiful rough collies & of course always want to keep them safe. Since Collies and cats go together so well, I have to include this caution for cats: Some ingredients used to kill ticks, such as permethrin (used in K9 Advantix and other products) and amitraz (used in Certifect and the Preventic collar), are toxic to cats, which can be a problem in a household that includes both, especially if they are friendly with each other. If you have cats that share sleeping space with and/or like to groom your dogs, Advantix is probably not the best product for you. It seems unlikely for that much time to elapse before a reaction, but I would definitely consult with a veterinarian. I found it extremely helpful & educational. No toxicity was seen when affected dogs were given 28 to 35.5 mcg/kg monthly for one year. Personally, I would be concerned about missing a daily dose. It also helps to know your dogs MDR1 statuses, which can be checked through places like Paw Print Genetics. To help with this, the product can be applied in more than one line between the neck and shoulder blades. Simparica TRIO for X-Large Dogs - 88 - 132 lbs - BROWN - 6 tablets (In Stock) $116.95: . Material name: Simparica Trio Version #: 01 Issue date: 07-01-2019 SDS US. Mar 2013. My two cats were father and son so probably carried the same gene. I know Simparica is more convenient since it means giving one monthly preventive instead of two, but the trade-off with the combo meds is that theyre usually stronger. Where can I get them tested for MDR1 resistance. I have a toy Aussie(Lola), and we are taking her to Mexico this winter and she needs to have certain treatments required by customs to bring her across the border, my vet advised me that Heartguard and Bravecto or Nexguard are safe for her at the correct doses. As with any topical product, monitor your pet for signs of skin irritation, and give them a bath within 24 hours to wash it off if signs of irritation are seen. My thought was to put on a collar in the morning and take it off at night when she will safely be back in the house. If you found this post helpful, you can leave me $1 or more tip on vocal.media or purchase one of our recommended dog products from Amazonso we can buy more dog supplies ourselves! He loves the taste of Simparica Trio and it's like a treat . An added benefit is it has been around long enough that cheaper generic products are available, some of which Ive tried and found to be as effective as Frontline. It is supposed to repel mosquitoes as well but I am very nervous about not using a heart worm preventative. My personal veterinarian is MDR1-aware and only prescribes Interceptor (probably the safest heartworm med) and Credelio (an oral flea/tick medication alternative to Nexgard). I actually ended up choosing Interceptor Plus along with Credelio after looking at your research and getting some advice from fellow Aussie owners. Based on its limited coverage of external parasites, cautionary potential side effects label, and its non-endorsement for pregnant or nursing females, I decided I could do better for my dogs. I went through Paw Print Genetics to save money. Capstar specifically targets adult fleas, so it is best paired with a product like Sentinel. Fleas were treated with effifax, active ingredient fipronil. I didnt see the link for the drug compatibility. If youre hoping for a quick, easy skim and just want to know which pest protections are considered safe, Ill list those first under each heading, followed by the use with caution category, and finally the not safe options. Hi Emily, do you know if panacure is a safe wormer? Please tell me if I am wrong. Is this true? The effects of the mutation vary in severity, depending on whether the dog carries one or two copies of the mutation. . Now: $92.79. 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